Discover, rate, and discuss biology preprints.

This study tests RAGE antagonism's effect on diabetic tendon healing and homeostasis, finding no improvement in healing but transient disruption in control tendons.

This study shows that inhibiting HDAC6 restores autophagic flux in endothelial cells under low shear stress, reducing atherosclerotic lesion formation.

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

This study investigates whether autism or autistic traits are associated with increased circular inference, a computational model of impaired Bayesian inference, but finds no such association.

This study shows that Compound A reduces lung inflammation and improves alveolarization in a neonatal rat model of bronchopulmonary dysplasia.

This study identifies GDF8 as a mediator of liver-muscle crosstalk that contributes to muscle atrophy in liver disease and shows that targeting GDF8 can reverse these effects.

This study shows activin B promotes liver fibrosis initiation and progression by acting on hepatocytes and hepatic stellate cells, and its neutralization prevents and regresses fibrosis in mice.

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

This study evaluates neutral honey as a potential safe alternative to formalin for tissue fixation in histopathology, finding comparable staining results in some tests but weaker reticulin fiber staining.

This study shows that Nrf2 deficiency leads to hepatocyte dedifferentiation and reduced albumin production in a cholestasis model.

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

This paper presents an automated Raman micro-spectroscopy system for high-throughput cytology classification, improving reproducibility and integration into standard pathology workflows.

This study shows that SARS-CoV-2 replicates in taste Type II cells expressing ACE2, leading to disrupted stem cell turnover in taste papillae of infected patients.

This paper uses transfer learning to predict metastatic origin from H&E-stained tumor images, achieving higher accuracy than models trained on primary or metastatic tumors alone.

This study shows that airway epithelium from smokers and COPD patients retains memory of damage, with persistent structural and functional abnormalities in vitro.

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

The paper identifies DNA hypermethylation in regressed mouse papillomavirus lesions that may contribute to increased susceptibility to UV-induced cancer.

This study develops small molecule inhibitors targeting PBX1 transcription signaling, showing they suppress cancer cell growth and re-sensitize resistant tumors.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.