B. Gong

Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase

The paper identifies and characterizes the chm biosynthetic gene cluster responsible for chalkophomycin production in Streptomyces sp. CB00271 and proposes a biosynthesis model based on sequence analysis and structural modeling.

Exosomally targeting microRNA23a ameliorates microvascular endothelial barrier dysfunction following rickettsial infection

This study shows that exosomal miR23a from rickettsial-infected endothelial cells disrupts BMEC barrier function by targeting ZO-1, and that anti-miR23a exosomes can restore barrier integrity.

AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements

This paper introduces microfluidic cantilevers for single-cell mass measurement, achieving sub-nanogram sensitivity and demonstrating improved performance with polymer materials.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

Host EPAC1 modulates rickettsial adhesion to vascular endothelial cells via regulation of ANXA2 Y23 phosphorylation

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samples

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

An integrative structural model of the full-length gp16 ATPase in bacteriophage phi29 DNA packaging motor

This study reports the crystal structure of gp16-CTD and simulations of the full-length gp16, revealing its role in dsDNA packaging through interactions with pRNA and dynamic domain interplay, refining the inchworm-revolution model.

Cell-type apoptosis in lung during SARS-CoV-2 infection

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

Endothelial exosome plays functional role during rickettsial infection

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections

This study shows that ANXA2 depletion increases CMHs in rickettsia and Ebola virus infections by disrupting BBB tight junctions.

Diffusive Flux Analysis of Tumor Vascular Permeability for 3-Helix-Micelles in Comparison to Other Nanoparticles

This paper develops a mathematical model to quantify nanoparticle permeability in tumors using diffusive flux analysis, showing 3-helix-micelles have higher permeability than other nanoparticles in glioblastoma and colon cancer models.

Transcriptome Analysis of juvenile Pacific White Shrimp (Litopenaeus vannamei) with symptom of stunted growth

This study identifies virus-related genes associated with stunted growth in juvenile Pacific White Shrimp through transcriptome analysis.

The algae community in taxon Haptophyceae at the early bloom stage of Phaeocystis globosa in Northern Beibu Gulf in winter

This study investigates the Haptophyceae algae community in the northern Beibu Gulf during winter, identifying Phaeocystis globosa's abundance and its correlation with nitrate and temperature.

IL-25 induces beige fat to improve metabolic homeostasis via macrophage and innervation

This study shows IL-25 promotes beige fat browning through macrophage activation and innervation, improving metabolic homeostasis in obese mice.

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

This study shows that EPAC1 promotes ANXA2 translocation to endothelial cell surfaces, enhancing plasminogen to plasmin conversion and fibrinolysis.