Q. Chang

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Exosomally targeting microRNA23a ameliorates microvascular endothelial barrier dysfunction following rickettsial infection

This study shows that exosomal miR23a from rickettsial-infected endothelial cells disrupts BMEC barrier function by targeting ZO-1, and that anti-miR23a exosomes can restore barrier integrity.

ERα-LBD, a novel isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

The paper identifies ER-LBD, a novel estrogen receptor alpha isoform, which promotes breast cancer growth and resistance to endocrine therapy.

Host EPAC1 modulates rickettsial adhesion to vascular endothelial cells via regulation of ANXA2 Y23 phosphorylation

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis

This study identifies P4HA2-dependent prolyl hydroxylation of YAP1 as a suppressor of prostate cancer cell migration, invasion, and metastasis.

Cell-type apoptosis in lung during SARS-CoV-2 infection

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

Endothelial exosome plays functional role during rickettsial infection

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

Selectively increased autofluorescence at certain regions of skin may become a novel diagnostic biomarker for lung cancer

This study shows increased epidermal green autofluorescence in skin and nails of lung cancer patients and mice, suggesting it as a potential non-invasive diagnostic biomarker.

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections

This study shows that ANXA2 depletion increases CMHs in rickettsia and Ebola virus infections by disrupting BBB tight junctions.

Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex

This study identifies TRPA1 in vagus neurons as essential for detecting IL-1β to initiate the inflammatory reflex, reducing inflammation and improving survival in sepsis.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

This study shows that EPAC1 promotes ANXA2 translocation to endothelial cell surfaces, enhancing plasminogen to plasmin conversion and fibrinolysis.