Discover, rate, and discuss biology preprints.

This study shows OPG levels are elevated in fibrotic lung tissue and correlate with IPF disease progression and reduced lung function.

This study shows that inhibiting LOXL2 reduces renal tubulointerstitial fibrosis in a mouse model and affects TGF-β/Smad signaling.

This study tests a commercial autogenous vaccine for ballan wrasse against Aeromonas salmonicida vapA type V, showing high protection and immune response.

This paper evaluates strategies to control cucumber green mottle mosaic virus in greenhouses using disinfectants and resistant cucumber varieties, finding that specific cleaning methods and certain varieties reduce infection spread.

This study evaluates ischaemic postconditioning in equine jejunal ischaemia, finding reduced mucosal denudation and paracellular permeability in the postconditioned group.

This study shows that fat tissue loss in mice infected with Trypanosoma cruzi worsens cardiac parasite load, inflammation, and severity of chronic Chagas cardiomyopathy.

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

This study identifies RpoS as a key factor enabling enteric pathogens to colonize plants during disease, highlighting its role in nutrient metabolism and stress response.

The paper introduces CQU-ConceFT, a standardized version of the ConceFT algorithm, to analyze non-stationary time series and visualize spindle structures in EEG signals.

The paper shows that Eip74EF rescues VCP mutant phenotypes in Drosophila, while miR-34 overexpression is lethal, suggesting different roles for miR-34 targets in ALS-FTD.

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

This study examines how endogenous AngII levels change with exogenous AngII infusion and their impact on AAA and atherosclerosis in mice.

The paper identifies a regulatory loop between MITF and HERV-K Rec that influences melanoma progression from proliferative to invasive stages.

This study tests the antiviral effect of Cynodon dactylon extract on IMNV in shrimp, finding 98% survival rate with extract treatment.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study tests ivermectin's effect on coronavirus infection in mice, finding reduced viral load and liver damage compared to infected controls.

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

This study shows that CD-1 mice with induced pulmonary comorbidities develop severe lung inflammation and high mortality after SARS-CoV-2 infection.

The paper shows that enzyme upregulation correlates with autophagic failure in GM1 Gangliosidosis, suggesting autophagy impairment as a potential biomarker for disease progression.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.