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The paper develops computational models of renal Ca2+ and Mg2+ transport in male rats to study the effects of diuretics on electrolyte handling.

This paper introduces a new red-emitting fluorescent indicator, CRhOMe, capable of both monitoring and measuring membrane potentials with improved signal-to-noise and quantification using fluorescence lifetime imaging microscopy.

This study shows that adaptive training plans using AI and readiness data improve runner performance and physiological responses compared to static training regimens.

The paper examines whether REM sleep incurs sleep debt by developing a novel measure of REM-like theta activity and finding it correlates with increased sleep debt.

The paper investigates how pulsation waves in the Ciona heart tube reverse due to bimodal rhythms from terminal pacemakers.

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

This study shows astrocyte aquaporin 4 mediates a tonic water efflux that maintains brain water homeostasis, astrocyte volume, and extracellular space remodeling.

This paper develops a method to measure CYP-EH PUFA metabolites in C. elegans using UPLC-MS/MS, showing similar metabolites to mammals and demonstrating changes with EH inhibition.

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.

The paper uses computational biology to analyze thrombus formation, showing platelet activation gradients and endothelial role in coagulation.

This study shows that Galectin-3 deletion improves vascular function in obese mice by reducing NOX1-mediated oxidative stress.

The paper shows osteocyte nicotinic acetylcholine receptors influence bone mechanoadaptation differently in males and females.

This study shows that cancer causes cardiac atrophy, dysfunction, and metabolic changes similar to heart failure in mouse models.

This study shows that PTTH loss-of-function in Drosophila extends lifespan by repressing NF-κB signaling in oenocytes during metamorphosis.

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

This study shows that astrocytes in the preBotzinger complex regulate breathing and arousal in rats, with inhibited signaling linked to calmness and enhanced signaling linked to arousal.

This study compares glycogen pool utilisation during 1- and 15-minute maximal exercises and examines the effects of low carbohydrate intake on glycogen storage and usage.

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.