Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PhysiologybioRxiv
The potential of dynamic physiological traits in young tomato plants to predict field-yield performance
S. Gosa, A. Koch, I. Shenhar…·M. Moshelion
The paper identifies physiological traits in young tomato plants that strongly correlate with field yield performance and resilience to drought.
DOI 10.1016/j.plantsci.2021.111122 - PhysiologybioRxiv
CHRONIC INFLAMMATION IN ULCERATIVE COLITIS CAUSES LONG TERM CHANGES IN GOBLETCELL FUNCTION
V. Singh, K. Johnson, J. Yin…·N. Zachos
This study shows that UC colonoids have persistent defects in mucus secretion despite reduced GC numbers, suggesting long-term epithelial dysfunction contributes to UC recurrence.
DOI 10.1016/j.jcmgh.2021.08.010 - PhysiologybioRxiv
Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction
K. Suresh Arulalan, J. Huayta, J. W. Stallrich, A. San-Miguel
This study examines how chemical mixtures affect oxidative stress in C. elegans under different environmental conditions, finding that heat stress suppresses responses while dietary restriction enhances them.
DOI 10.1093/exposome/osab005 - PhysiologybioRxivPreprint
Response of rhizobial strains on biochemical traits and nutrient uptake in Mungbean (Vigna radiata L. Wilczek) under moisture stress
The study evaluates the impact of rhizobial inoculation on biochemical traits and nutrient uptake in mungbean under moisture stress conditions.
DOI 10.1101/2021.03.16.435312 - PhysiologybioRxiv
Characterization of an Agarophyton chilense oleoresin containing PPARγ natural ligands with insulin-sensitizing effects in a C57BL/6J mouse model of diet-induced obesity and antioxidant activity in Caenorhabditis elegans.
C. Pinto, M. R. Ibanez, G. Loyola…·F. C. Bronfman
This study characterizes an oleoresin from Agarophyton chilense that activates PPARγ without adipocyte differentiation, improves insulin sensitivity in mice, and shows antioxidant activity in C. elegans.
DOI 10.3390/nu13061828 - PhysiologybioRxivPreprint
Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates
K. Yahara, V. P. Tuan, H. D. Q. Dung…·Y. Yamaoka
This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.
DOI 10.1101/2021.03.15.435401 - PhysiologybioRxivPreprint
Broccoli sprout Sulforaphane affected hemodynamics and aorta myogenic spontaneous rhythmic contraction in sanitized water uptake mice
L. Li, L. Gao, T. Wang…·Y. Wang
This study examines how broccoli sprout sulforaphane affects hemodynamics and aortic myogenic contractions in mice consuming saline water.
- PhysiologybioRxiv
Deficiency of peroxisomal L-bifunctional protein (EHHADH) causes male-specific kidney hypertrophy and proximal tubular injury in mice
P. Ranea-Robles, K. Portman, A. Bender…·S. M. Houten
This study shows that EHHADH deficiency in mice causes male-specific kidney hypertrophy and proximal tubular injury, linked to androgen effects on peroxisomal metabolism.
DOI 10.34067/kid.0003772021 - PhysiologybioRxivPreprint
Independent mechanisms underlie the protective effect of dietary polyunsaturated fatty acid supplementation and G&alphaz deficiency on the early type 1 diabetes phenotype of Non-obese diabetic (NOD) mice
R. J. Fenske, H. N. Wienkes, D. C. Peter…·M. E. Kimple
This study shows that EPA-enriched diets and Gz deficiency both improve glucose tolerance in NOD mice but through distinct mechanisms.
DOI 10.1101/2021.03.13.435254 - PhysiologybioRxivPreprint
Systemic application of the TRPV4 antagonist GSK2193874 induces tail vasodilation in a mouse model of thermoregulation
F. O'Brien, C. A. Staunton, R. Barrett-Jolley
This study shows that the TRPV4 antagonist GSK2193874 increases tail blood flow in mice across all temperatures, suggesting central rather than peripheral vascular effects on thermoregulation.
- PhysiologybioRxiv
A specialist flea beetle manipulates and tolerates the activated chemical defense in its host plant
T. Sporer, J. Koernig, N. Wielsch…·F. Beran
This study investigates how the flea beetle Phyllotreta armoraciae sequesters glucosinolates from its host plant and tolerates their hydrolysis, showing that plant myrosinases reduce sequestration but beetles avoid gut hydrolysis through absorption and inactivation of myrosinases.
DOI 10.3389/fpls.2021.645030 - PhysiologybioRxiv
Can offsetting the energetic cost of hibernation restore an active season phenotype in grizzly bears (Ursus arctos horribilis)?
H. T. Jansen, B. D. Evans Hutzenbiler, H. R. Hapner…·C. T. Robbins
Feeding hibernating grizzly bears glucose partially restores metabolic parameters but not body temperature, suggesting metabolic suppression is an active process.
DOI 10.1242/jeb.242560 - PhysiologybioRxivPreprint
KS-WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates
C. R. Boyd-Shiwarski, R. T. Beacham, J. A. Lashway…·A. R. Subramanya
This study shows KS-WNK1 amplifies NCC activity in response to potassium changes via WNK bodies, leading to sex-specific renal salt-wasting and blood pressure sensitivity.
- PhysiologybioRxivPreprint
Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in Mice
E. E. Ha, G. I. Quartuccia, R. Ling…·R. C. Bauer
This study shows that adipocyte Trib1 regulates plasma adiponectin, cholesterol, and triglycerides in mice, confirming human genetic associations and revealing a novel mechanism for Trib1's role in lipid metabolism.
DOI 10.1101/2021.03.11.434882 - PhysiologybioRxiv
Chronic exercise protects against the progression of renal cyst growth and dysfunction in rats with polycystic kidney disease
J. Qiu, Y. Sato, L. Xu…·O. Ito
This study shows that chronic exercise in PCK rats reduces renal cyst growth and dysfunction by modulating specific signaling pathways.
DOI 10.1249/mss.0000000000002737 - PhysiologybioRxiv
Growth differentiation factor 15 increases in both cerebrospinal fluid and serum during pregnancy
U. Andersson-Hall, P. Svedin, C. Mallard…·A. Holmäng
This study measures GDF15 levels in cerebrospinal fluid and serum during pregnancy and finds they are significantly higher than non-pregnant levels, with CSF levels correlating with serum levels during pregnancy.
DOI 10.1371/journal.pone.0248980 - PhysiologybioRxiv
Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya
S. Kariuki, Z. A. Dyson, C. Mbae…·G. Dougan
The study investigates typhoid dynamics in Kenya, finding high multidrug-resistant H58 S. Typhi prevalence in both cases and controls, suggesting carriers contribute to community spread.
DOI 10.7554/elife.67852 - PhysiologybioRxivPreprint
Insulin-stimulated adiponectin secretion in pregnancy is mediated by inhibition of adiponectin ubiquitination and degradation and is impaired in obesity
I. L. M. H. Aye, F. J. Rosario, A. Kramer…·T. Jansson
The paper investigates how insulin affects adiponectin secretion in pregnancy and shows that obesity impairs this process through increased ubiquitination and degradation of adiponectin.
- PhysiologybioRxiv
Bi-directional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes
C. H. Peters, P. Liu, S. Morotti…·C. Proenza
This study quantifies the funny current (If) in murine sinoatrial node myocytes, showing its persistent activity and dual role in driving membrane potential oscillations during pacemaking.
DOI 10.1073/pnas.2104668118