P. Ranea-Robles

Overfeeding does not increase energy expenditure or energy excretion in mice

This study shows overfeeding in mice does not increase energy expenditure or excretion, and weight gain is mainly countered by reduced food intake.

Cross-species comparison of pregnancy-induced GDF15

This study compares GDF15 expression during pregnancy across species, finding significant differences in plasma levels and expression between humans/macacaques and rodents.

A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

Deficiency of peroxisomal L-bifunctional protein (EHHADH) causes male-specific kidney hypertrophy and proximal tubular injury in mice

This study shows that EHHADH deficiency in mice causes male-specific kidney hypertrophy and proximal tubular injury, linked to androgen effects on peroxisomal metabolism.

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse

This study examines the effects of dietary restriction on plasma metabolites and cardiac function in LCAD KO mice, finding minimal impact on metabolites and no cardiac remodeling.