Discover, rate, and verify biology preprints.

Synergy-informed bilevel optimization reveals joint-specific benefits for realistic exoskeleton torque prediction

This study uses synergy-informed bilevel optimization to improve exoskeleton torque prediction by preventing non-physiological muscle shutdown, showing better alignment with experimental data.

Redox regulation of 2-carboxy-D-arabinitol 1-phosphate phosphatase in Fabaceae is associated with high Rubisco dark inhibition

The paper identifies a conserved cysteine pair motif in CA1Pase linked to redox regulation and inhibitor degradation in Fabaceae species.

Mitochondrial transplantation redirects rather than suppresses the inflammatory response in primary human monocytes

This study transplants mitochondria into human monocytes, altering their inflammatory response by reducing pro-inflammatory mediators and increasing IL-10.

Junction-level imaging and modeling of transient leaks in epithelia predicts a dynamic tight junction strand network

The paper uses imaging and modeling to study transient leaks in epithelial tight junctions, finding that dynamic strand breaking and sealing explain leak behavior at the junction level.

Integrating bacterial genomics and host transcriptomics links Burkholderia pseudomallei variation to melioidosis mortality and neutrophil responses

The yeast Gcn2 protein kinase mediates P-body formation both through its activity with eIF2α and with non-canonical substrates

This study shows that yeast Gcn2 promotes P-body formation through eIF2α phosphorylation and Smu2-dependent mRNA granule maturation, even when eIF2α phosphorylation is blocked.

Improving Consistency in Colorectal Cancer Genetic Risk Assessment and Return of Results Through an Integrated Polygenic Risk Score

This paper develops a stable polygenic risk score for colorectal cancer by integrating multiple existing scores, improving individual-level risk classification consistency without sacrificing population-level performance.

HIF1A-AS2 Regulates Hypoxia-Driven HIF Isoform Switching in Human Endothelial Cells

This study shows HIF1A-AS2 regulates the switch from HIF-1 to HIF-2 signaling in hypoxia by reducing HIF1A expression and increasing HIF-2 activity in endothelial cells.

Thienothiazolocarboxamides: rapidly cidal agents causing catastrophic thiol collapse in Mycobacterium tuberculosis.

This paper identifies thienothiazolocarboxamides as rapidly cidal antituberculosis agents that cause thiol collapse in Mycobacterium tuberculosis through EthA-mediated activation.

Rapid environmental DNA detection with isothermal amplification methods: a comparison with the real-time quantitative PCR in the natterjack toad (Epidalea calamita).

This paper compares isothermal amplification methods (LAMP and RPA) with qPCR for detecting natterjack toad eDNA, finding RPA matches qPCR sensitivity while LAMP is less sensitive.

Ogg1 regulates context-dependent glial states in Alzheimer's disease

This study shows Ogg1 has opposing effects on glial states in Alzheimer's disease, improving memory and reducing amyloid burden in a mouse model while impairing memory under physiological conditions.

Structural and functional examination of Neisseria gonorrhoeae TfpC reveals a dynamic two-domain architecture required for type IV pilus function

This study examines the structure and function of Neisseria gonorrhoeae TfpC, revealing its dynamic two-domain architecture essential for type IV pilus function.

Natural regeneration in tree islands drives long-term recovery of native forest-associated woody species in oil palm landscapes

BEHAV3D-Explorer enables natural language-assisted profiling of 3D cellular dynamics

BEHAV3D-Explorer provides a user-friendly platform for analyzing 3D live-cell imaging data using natural language guidance to select analysis strategies and configure workflows.

Thermosensory pathway makes a U-turn to respond to heat

The paper shows that heat stress reverses the growth-promoting thermomorphogenesis pathway in Arabidopsis by suppressing auxin and PIF4 in cotyledons, revealing an active molecular mechanism.

A Common Recognition Architecture Across Memory Scales

This study shows that recognition signals in memory tasks share a common neural format across different memory scales, with changes in timing, strength, and behavioral relevance.

Psychoneuroimmunology of Viral Hepatitis and Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

This study conducts a systematic review and meta-analysis of 24 studies to explore the link between viral hepatitis, hepatocellular carcinoma, and neuropsychiatric disorders, identifying immune and inflammatory mechanisms.

Slowed aquatic invasion coincides with intensified research and prevention in Minnesota, USA

The paper measures the effectiveness of aquatic invasive species prevention in Minnesota by showing slowed invasion rates alongside increased prevention efforts and simulations suggesting a 20-53% reduction in new invasions.

PP271, a novel bacteriophage primase-polymerase, enables Primer-Free DNA Amplification

This paper characterizes PP271, a novel bacteriophage PrimPol enzyme, showing it can synthesize DNA primers that are efficiently extended by Phi29 DNA polymerase for primer-free amplification.

Early visual cortex is not functionally necessary for temporal attention: A TMS study