Discover, rate, and discuss biology preprints.

RNA-SpecFlow synthesizes histology images conditioned on RNA data, showing that increased detection counts can coincide with reduced segmentation agreement.

The paper introduces taxon-in-context to capture individualized microbial context in the human gut microbiome, showing that microbes occupy different contexts across individuals and over time, improving recurrence prediction.

This study shows the subthalamic nucleus (STN) encodes reward value and updates reward associations during cognitive flexibility tasks.

This paper introduces FBA-Hyb, a hybrid model integrating metabolic networks into bioprocess modeling, achieving higher predictive accuracy and stoichiometric consistency.

Genedex integrates gene signatures from Alzheimer's disease studies to contextualize gene expression across pathology, cell types, and brain regions, revealing new insights into disease mechanisms.

This study identifies HD-LINC, a human-specific lncRNA, as a driver of lipid droplet-associated neurodegeneration in Huntington's disease, showing its role in lipid metabolism and neuronal death.

This paper reconstructs the visual experiences of desert ants during foraging using integrated tracking, habitat mapping, and compound eye modeling.

The paper uses single-cell RNA-seq and explainable AI to identify transcriptional features distinguishing invasive from non-invasive TNBC cells in a cell line, finding EMT-related and inflammatory genes as key predictors.

The paper identifies localized chromatin rewiring in rice's stable 3D genome that coordinates rhythmic transcription across the circadian cycle.

This study reconstructs mouse vasculogenesis using single-cell and spatial analyses, revealing a transient vascular-primed state and the role of VEGF in endothelial specification.

This study shows that removing glycogen in Synechocystis sp. PCC 6803 increases ethylene production but creates a metabolic constraint involving 2-oxoglutarate, GS-GOGAT, and phosphate.

The paper characterizes the biophysical interactions between XIST E-Repeats and RNA-binding proteins, revealing cooperative binding and phase separation behavior that informs XIST's chromatin-modulating function.

This study identifies SMIM1 as a key regulator of an alternative iron uptake pathway through hemoglobin binding and lysosomal iron release, with implications for iron homeostasis and erythropoiesis.

This study investigates stomatal decoupling under extreme heat by comparing two rainforest and two semi-arid tree species, finding that decoupling occurs in some species but not others, linked to transpirational cooling capacity and light conditions.

This study shows EzrA coordinates septal organization and nucleoid occlusion in S. aureus by spatially coupling peptidoglycan synthesis with surface protein display and preventing chromosome guillotining.

This paper develops an enzymatic platform to synthesize diverse mAb glycoforms and uses them to study α-Gal immunogenicity and FcγR binding.

This study identifies blood-based biomarkers that predict early tuberculosis culture conversion by analyzing mRNA and small RNA changes during treatment.

This study investigates the association between brain age gap and externalising behaviours in youth, finding a cross-sectional link that weakens over time.

This study identifies CK1 as a regulator of lysosomal fitness and ferroptotic sensitivity in glioblastoma stem-like cells through molecular glue degraders.

This study reveals how two distinct inhibitors affect the conserved N-terminal docking groove of connexin-46/50 gap junctions, leading to different conformational changes and providing structural insights into broad isoform activity.