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This study shows that combining multiple low-dose inhibitors targeting the same oncogenic driver can delay drug resistance in cancer models.

This study compares viral replication and host responses in airway epithelial cells to distinguish pathogenic from seasonal coronaviruses, finding HCoV-229E induces severe epithelial injury despite limited replication.

The paper identifies HELM, a LOV-domain protein essential for phototaxis in brown algae, and shows its role in light-directed movement and flagellar fluorescence.

This study evaluates the efficacy of different GLP-1R agonist peptides delivered via AAV vectors in diet-induced obese mice, finding that Ex4 and Ex4-Fc variants show significant weight loss and metabolic improvements compared to GLP-1 and Gly8.

Open-BEATBox enables continuous, autonomous assessment of complex mouse behavior, generating more trials and reducing experimenter workload without adverse effects.

The paper develops SPARTA for in situ genetic reprogramming of native microbiomes and introduces ScRibe-seq to identify engineered taxa, demonstrating functionality across diverse environments.

ProClust assesses the statistical significance of clusters in scRNA-seq data to refine overclustering and distinguish biologically meaningful subpopulations.

This paper develops a multimodal miR-15a-based therapeutic that overcomes resistance to gemcitabine and daraxonrasib in PDAC by combining gene regulation and nucleotide metabolism disruption, showing potent antitumor effects in vitro and in vivo.

The paper examines if somatic symptom burden is linked to reduced reactive aggression in healthy adults, finding that higher symptom burden correlates with lower noise intensity choices in an aggression task.

This paper introduces PertVI, a deep generative model that disentangles treatment effects from cellular state and batch effects in single-cell perturbation data, revealing state-specific transcriptional responses.

This study identifies molecular mechanisms of Quizartinib resistance in FLT3 mutants using molecular dynamics simulations and experimental validation, showing distinct electrostatic and hydrophobic effects of D835Y and F691L mutations.

This study evaluates how fixation affects traction force microscopy measurements, finding that glutaraldehyde preserves live-cell-like metrics better than other protocols.

LuCEMe is a luciferase-based method to assess cellular metabolism in various systems, revealing metabolic differences in cancer and immune cell interactions.

This study shows that excluding low-frequency variants and indels in fine-mapping leads to false discoveries and introduces SuSiE-OUT to address this issue.

The paper identifies two competing pathways that influence neuronal firing patterns and hyperexcitability, showing how anti-seizure drugs selectively target these pathways.

The paper introduces a method to identify key players in rare conformational transitions of proteins by analyzing transition corridors and testing their impact through computational and mutational approaches.

This study identifies inactivating CSTF2 variants in males with intellectual disability and shows they disrupt intronic polyadenylation patterns, linking CSTF2 to neurodevelopmental disorders.

This study investigates the adaptive radiation of butterflyfishes on coral reefs, finding a recent radiation in the Late Miocene linked to ecological opportunities from coral reef turnover and coral diversification.

The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.

The paper evaluates a rapid Nanopore-based microbiome profiling workflow for women's health outreach at a music festival, demonstrating its feasibility for fieldable citizen science initiatives.