Discover, rate, and discuss biology preprints.

This paper shows that timed WNT pulses can specify distinct neural domains in human pluripotent stem cells, enabling the generation of specific neuron and progenitor types.

This paper develops a microfluidic platform integrating fallopian tube organoids to study epithelial function and disease, showing viable cultures and comparable cell health to intact organoids.

Neuroline integrates multimodal neurophysiology data into a standardized format, enabling FAIR data sharing and cross-modal analysis.

The paper evaluates the hemodynamic impact of a novel STJ reconstruction in ATAA repair using computational modeling, showing restored sinus vortices post-surgery.

This study shows that the LMD-3 mutation in C. elegans causes reproductive failure by disrupting lysosomal function and proteostasis, which can be reversed with vitamin B12 supplementation.

This study reconstructs the plant organellar homologous recombination pathway in Arabidopsis, showing that AtRecA1-mediated recombination is enhanced by plant-specific ssDNA-binding proteins, while AtRecA2 and AtRecA3 require these proteins for activity.

The paper quantifies delayed coral mortality after a marine heatwave, showing prolonged impacts on reef recovery and highlighting size-dependent bleaching responses in Pocillopora.

The paper identifies ERR-specific genomic targets in adult Drosophila adipocytes using NanoDam, revealing its role in regulating metabolic pathways.

This study shows that early life adversity increases prosocial helping behavior in rats and is associated with changes in brain-wide neural activity and network organization.

This study compares three lipid force fields for membrane remodeling using molecular dynamics simulations, finding differences in pore formation and stability under enhanced sampling methods.

The paper shows cancer cells in the lung take up cysteine and cystine efficiently, and the reduced tumor microenvironment supports their growth and resistance to oxidative stress.

This study identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas using genomic, transcriptomic profiling, and drug testing in patient-derived models.

This study evaluates a bivalent Lassa virus mRNA vaccine in mice and guinea pigs, showing it provides complete protection against lethal infection, whereas monovalent vaccines do not.

The paper identifies how stratified palliobulbar pathways control respiratory timing and acoustics of learned vocalizations in zebra finches, revealing distinct roles for medulla and midbrain periaqueductal gray (PAG) projections.

This study shows that neutrophils protect against cryptococcosis by limiting CCR2-dependent monocyte-driven immunopathology, even without affecting fungal burden.

This study shows that stabilizing the CHI3L1-Gal3BP complex with LZ6 improves the glioblastoma immune microenvironment and extends survival, both alone and when combined with PD-1 blockade.

The paper identifies a conserved ADAR1 dsRBDIII motif predicted to interact with PKR and shows that this interaction is RNA-dependent.

This study links white matter microstructure to electrophysiological timing and naming performance by analyzing diffusion, electrophysiological, and behavioral data.

The paper shows that PPC neurons encode hand-eye movements additively, allowing modular decoding of coordinated movements.

This study profiles mRNA and miRNA expression in pediatric Burkitt leukemia and lymphoma, identifying dysregulated miRNA-mRNA networks and key pathways involved in proliferation and immune signaling.