Discover, rate, and discuss biology preprints.

Agent3Diso identifies disease-relevant molecular forms by integrating molecular data with agentic reasoning to guide therapeutic discovery beyond gene-level targets.

This study determines the structure of DFCP1 and shows it forms a barrier that concentrates PI3P for lysosomal repair.

BUDDY is a web platform that streamlines the functional modeling of human missense variants using yeast orthologs, reducing bioinformatic preparation time and enabling non-experts to design experiments.

The paper develops Pheno2Seq to study gene expression changes in foraminifera life cycle transitions, identifying genes involved in nuclear dynamics and genome stability.

The paper identifies consistent acute scalp EEG signatures of anterior thalamic DBS in epilepsy, showing gamma power enhancement and aperiodic parameter changes across multiple sessions.

The paper performs a meta-analysis of six TOF snRNA-seq datasets to identify compartment-resolved ciliary transcriptional dysregulation, finding module-specific gene expression patterns in TOF endothelium.

The paper quantifies how species diversity affects irreducible dynamical heterogeneity in ecological communities near equilibrium.

This study evaluates synthetic graph generators for rabies transmission modeling, finding that the degree-corrected stochastic block model best reproduces empirical contact networks and outbreak dynamics for short-infectious-window pathogens.

This study shows that low-order MLKL oligomers cause irregular membrane defects during necroptosis, disrupting plasma membrane integrity without forming defined pores.

This study shows that features of mitochondrial ribosomes, such as host protein acquisition and structural changes, are also present in an ancient insect endosymbiont, suggesting these traits arise from endosymbiont ancestry rather than mitochondrial specificity.

This study shows that Gnpat-knockout mice exhibit testicular interstitial remodeling and germ-cell loss due to ether-lipid deficiency, with no DNA-damage checkpoint activation.

The paper identifies recurring brain states across tasks and links their dynamics to trial-to-trial performance and individual response strategies.

This study shows BRN2 is essential for preserving melanocyte lineage integrity after ionizing radiation, but not for normal maintenance.

The paper shows that human endothelial cells respond to sustained sub-threshold acoustic stimulation with delayed activation, unlike immediate responses to over-threshold mechanical stimulation.

The paper identifies bottlenecks in MHC-I antigen presentation by Mtb, showing that only a small fraction of predicted binders are actually presented, and develops computational models to improve prediction.

The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.

This study compares dual-enzyme spore display with mixed single-enzyme spores for cellulose hydrolysis, finding that mixing single-enzyme spores yields higher glucose production.

This paper develops a synthetic VEEV reporter virus for high-throughput antiviral screening, identifying inhibitors of VEEV replication using FDA-approved compounds.

This study shows that repeated pup exposure converts virgin male mice to a parental state via calcitonin receptor-expressing neurons in the medial preoptic area.