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This paper identifies MA2, a small-molecule agonist of MDA5 that enhances antiviral and antitumor immunity by dynamically stabilizing MDA5 filaments.

Bolero predicts cell-state-specific gene regulation from DNA across species by integrating cell-state embeddings and biological variables.

This paper demonstrates the use of optogenetic and sonogenetic biological actuators to pace unmodified cardiac tissue with high spatial precision and rapid integration.

This paper introduces a 3D soft carbon neural interface fabricated via depth-tunable laser drawing, showing improved in-vitro and in-vivo performance and reduced MRI artifacts compared to 2D alternatives.

This paper demonstrates the use of plant cells to create adaptive, programmable living materials with photosynthetic and electrochemical functionalities.

The paper demonstrates a non-invasive nasal swab platform with single-cell Western blotting for Alzheimer's disease biomarker detection, showing superior diagnostic performance compared to blood-based methods.

This study shows that IRE1α assembly into filaments is dynamically regulated by unfolded proteins and BiP through opposing mechanisms.

XplainTDA identifies molecular determinants of topological structures in single-cell multi-omics data through perturbation-based analysis.

The paper identifies developmental trajectories that organize valence-specific circuit assembly in the central amygdala using single-cell profiling and molecular analysis.

The paper presents a time-course single-nucleus ATAC-seq dataset from rat skin wounds, revealing chromatin accessibility changes across repair phases.

ALLCAPS is a deep-learning tool for in silico pneumococcal serotyping that outperforms existing methods and identifies novel serotypes.

This study identifies NHE1 as a regulator of T-ALL leukemia-propagating activity and mitochondrial fitness, showing its therapeutic potential.

This study develops and validates two fluid-structure-growth models to predict long-term outcomes of vascular grafts in endogenous tissue restoration.

The paper introduces Capiti, an edge-deployed system that detects pathogenic protein function during DNA synthesis by analyzing valve control signals, outperforming existing sequence-based screening tools.

The paper introduces a benchmark dataset and tool for cross-lab quantification of mouse social behavior, achieving high-resolution and reproducible classification.

This study compares buffered Lugol's iodine and phosphotungstic acid for contrast-enhanced μCT of dragon lizard brains, finding buffered Lugol's iodine provides better contrast and less tissue shrinkage.

The paper introduces a data model for longitudinal multimodal biomedical cohorts, demonstrating its ability to manage heterogeneous data across multiple modalities and study visits.

This study shows that reducing nitrate supply under salt stress improves tomato fruit quality and mitigates chlorophyll loss, with transcriptomic changes supporting these physiological benefits.

This paper introduces an Oxford Nanopore sequencing framework for hantavirus genome assembly and variant analysis, revealing defective viral genomes as a new feature of hantavirus populations.