Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PhysiologybioRxivPreprint
mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation
Gaia Fabris, Simon Biaudet, Atte Hallasaari…·Ville Hietakangas
This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.
DOI 10.64898/2026.10.29.762847 - NeurosciencebioRxivPreprint
Naturalistic recall preserves temporal specificity despite cortical feature reorganization
Shikang Peng, Brian Levine, Bradley R Buchsbaum
The paper analyzes fMRI data to show that temporal specificity in recall is preserved despite reorganization of feature representations across the cortex during recall of a narrative episode.
- BiophysicsbioRxivPreprint
Multispecies transport shapes electrochemical environments in perforated cells
Yikang Guan, Hengyu Li, Miao Shi…·Shiyu Xia
The paper models multispecies transport through gasdermin pores to explain how pore formation leads to cell swelling and osmotic changes.
DOI 10.64898/2026.11.03.764109 - Animal Behavior & CognitionbioRxivPreprint
Mating behaviour, mate choice, and reproduction in Tyrophagus curvipenis (Acari: Acaridae)
Shi-Sen Ye, Keshi Zhang, Zhi-Qiang Zhang
This study examines mating behavior, mate choice, and reproductive outcomes in Tyrophagus curvipenis, finding that mating frequency affects fecundity but not pre-oviposition period.
DOI 10.64898/2026.11.01.763476 - MicrobiologybioRxivPreprint
Rhizobia transform legume nodules via native T-DNA transfer systems
Shan-Chi Hsieh, Erh-Min Lai, Chih-Horng Kuo
The paper identifies native T-DNA transfer systems in rhizobia that deliver cargo genes into legume nodules, showing they share similarities with Agrobacteria-mediated transformation but have distinct regulatory mechanisms.
DOI 10.64898/2026.11.03.763973 - GeneticsbioRxivPreprint
The role of the fruitless P3 transcript in development in Drosophila melanogaster
Sara A. Kulinski, William Yeung, Amanda J. Moehring
This study investigates the role of the fruitless P3 transcript in Drosophila development, finding it essential for pupal development and metamorphosis, with distinct effects compared to complete fruitless loss.
DOI 10.64898/2026.11.03.764014 - Pharmacology & ToxicologybioRxivPreprint
Complementary chemical and effect-based risk assessments reveal ecotoxicological risks in Caribbean coastal bays and coral reefs
Nienke C.J. van de Loosdrecht, Milo L. de Baat, Mark J.A. Vermeij…·Jasper M. de Goeij
The paper assesses chemical pollution and ecotoxicological risks in Caribbean coastal bays and coral reefs using chemical analysis and bioassays, finding that bays act as pollution sources while reefs show mixture toxicity.
DOI 10.64898/2026.11.02.763482 - BiophysicsbioRxivPreprint
Electrostatic control of conformational dynamics drives proton translocation in respiratory Complex I
Jobst Liebau, Patricia Saura, Sofia Badolato…·Ville R. I. Kaila
The paper investigates how electrostatic interactions control conformational changes and proton translocation in Complex I using a combination of experimental and computational methods.
DOI 10.64898/2026.11.03.764137 - NeurosciencebioRxivPreprint
A subtype-specific gene regulatory program controls differential circuit integration of deep CA3 pyramidal neurons
Joris de Wit, Danie Daaboul, Jeroen Vandensteen…·Stein Aerts
The paper identifies ST18 as a regulator of deep CA3 pyramidal neuron identity, showing its role in restricting a superficial-like program and shaping circuit integration through molecular and electrophysiological changes.
- NeurosciencebioRxivPreprint
The behaviour bends, the code holds: working-memory category information in the multiple-demand network across graded interruption
Olga Leticevscaia, Eva Feredoes
This study investigates how the multiple-demand network maintains working memory during task interruptions, finding that neural representations of category information remain stable despite behavioral costs.
DOI 10.64898/2026.11.03.763342 - Plant BiologybioRxivPreprint
Anionic lipids stabilize etioplast prolamellar bodies and facilitate thylakoid biogenesis during etioplast-to-chloroplast differentiation
Akiko Yoshihara, Risa Uwatoko, Keiko Kobayashi…·Koichi Kobayashi
This study investigates the role of anionic lipids in etioplast-to-chloroplast differentiation, finding that phosphatidylglycerol is crucial for membrane processes while sulfoquinovosyldiacylglycerol supports chloroplast development under PG limitation.
DOI 10.64898/2026.10.31.763292 - NeurosciencebioRxivPreprint
Monoaminergic changes are associated with impaired neurogenesis along the longitudinal axis of the hippocampus in ageing and dementia
Kathryn J Mathews, Amr H Abdeen, David Mor…·Kay L Double
The paper examines monoaminergic changes and their association with impaired neurogenesis in the hippocampus across aging and Parkinson disease dementia.
DOI 10.64898/2026.11.03.764096 - Cell BiologybioRxivPreprint
The mechanism of cysteine sensing by LRRC58
Emma C. Fink, Hilina B. Woldemichael, Nikhit Kambdur…·Edward T. Chouchani
This study identifies how LRRC58 senses cysteine through structural changes that regulate CDO1 binding and cysteine homeostasis.
DOI 10.64898/2026.11.03.763985 - BioinformaticsbioRxivPreprint
Context, not contradiction: a pan-cancer framework for conforming and nonconforming co-expression programmes
Safir Ullah Ullah Khan, Ava Storgard, Alfonso Méndez Tenorio, Dwayne G. Stupack
The paper introduces a framework to analyze pan-cancer co-expression programs by addressing artifacts in existing methods, showing that gene expression patterns differ between cancer types.
DOI 10.64898/2026.11.02.763469 - Systems BiologybioRxivPreprint
Photographic age gap is associated with frailty and predicts survival in laboratory mice
Kevin Perez, Clement Molina, Luca Tagliafico…·Marco Malavolta
This paper uses photographs of mice to predict biological age and finds that older appearance correlates with frailty and shorter survival.
- BioinformaticsbioRxivPreprint
All-Atom Structure Tokenizer: AtomLM-9b for Biomolecular Structure Prediction
Jiaxian Yan, Dongchu Xie, Zhicai Wang…·Zaixi Zhang
The paper introduces AtomLM-9b, a language model using an all-atom structure tokenizer to predict protein structures with performance comparable to AlphaFold 3.
DOI 10.64898/2026.11.03.763913 - ImmunologybioRxivPreprint
Arginine activates a conserved sphingolipid defense axis against infection
Shuncai Han, Mengge Li, Geoff M. Gurr…·Xiaofeng Xia
This study shows arginine activates a conserved sphingolipid pathway in insects, promoting antibacterial effects through ceramide accumulation, independent of classical immune responses.
DOI 10.64898/2026.11.03.763873 - BiophysicsbioRxivPreprint
STRUCTURAL PLASTICITY ALLOWS DOUBLECORTIN AND DRUG-STABILIZED MICROTUBULES TO ACCOMMODATE EACH OTHER
Varun Ramaswamy, Szymon W Manka, Darsh D Sharma…·Carolyn Moores
This study shows that taxane-stabilized microtubules can adopt 15-protofilament structures, which DCX can bind through conformational remodeling, contrasting with the rigid GMPCPP-stabilized lattice.
DOI 10.64898/2026.11.03.763982