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This study isolates and characterizes extracellular vesicles from Aloe vera gel, showing that mature manually extracted vesicles have superior antioxidant, anti-inflammatory, and antifibrotic effects.

The paper identifies domain-specific phenotypic effects of MACF1 variants outside the GAR domain, revealing broader neurodevelopmental and craniofacial anomalies.

This study evaluates how large language models improve P300 speller performance, showing up to 75% gains in typing speed and approaching theoretical limits.

The paper identifies 92 functional regulatory variants associated with adolescent idiopathic scoliosis using massively parallel reporter assays in chondrocytes.

This study compares antibiotic resistance development in E. coli across LB broth, synthetic wastewater, and real wastewater, finding synthetic wastewater better predicts growth and resistance than LB.

This paper decodes emotion from EEG during overt and imagined vocalisation, finding that involuntary facial muscle activity contaminates EEG and contributes to emotion decoding.

In starved HEK293T cells, RIOK3 recruits TUT7 and DIS3L2 to 40S ribosomes; TUT7 adds 3′ oligo(U) tails to 18S rRNA and DIS3L2 degrades it 3′ to 5′.

This paper develops a biomechanical model of the brain to show that ventricular enlargement in iNPH causes mechanical strain in white matter, contributing to brain damage.

The paper investigates chronic proliferation and glia heterogeneity in CMT1A rat sciatic nerves, identifying RUNX2-positive Schwann cells and endoneurial fibroblasts as key contributors to disease pathology.

This study examines how very long branch taxa affect phylogenetic inference in Dioscoreales, finding that they reduce branch support and challenge current classifications.

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

This study identifies the planar cell polarity pathway as coordinating epithelial migration and functional zonation during intestinal development.

This study shows that embryonic depletion of D-aspartate in mice leads to increased NMDA receptor-dependent long-term potentiation in juvenile hippocampus, which is reversible with exogenous D-aspartate.

This study identifies inducible regulatory T cells as the mechanism for immune tolerance to corneal epithelial antigens, showing that this tolerance can be overcome by inflammatory priming.

The paper develops resources to identify cis-regulatory elements in the Parhyale hawaiensis genome using ATAC-seq and sequence conservation analysis.

This study uses spatial transcriptomics to analyze medulloblastoma tumor microenvironments, identifying high-risk features and spatial patterns linked to relapse.

The paper identifies a microprotein, TGCB, encoded by the lncRNA CHASERR, and shows its deletion is linked to neurodevelopmental disorders.

This study identifies CD22 upregulation in microglia due to oxidative stress in HD, which impairs phagocytosis and worsens disease progression.

This study finds that microfilaremic loiasis is associated with reduced IFN-γ T cell responses to SARS-CoV-2, while IgG responses remain similar across infection statuses.

This study shows that IP6K1 supports polyphosphate synthesis in mast cell granules by maintaining granule acidification via V-ATPase activity.