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This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.

This study shows that disrupting the amino acid stress response pathway reduces tumor growth in multiple aggressive cancers by targeting chronic metabolic stress adaptation.

This paper develops a forward-operator model to predict signal mixing in fMRI and shows that correcting for it improves coarse-resolution cortical mapping.

The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.

This study examines how antibiotics affect immune cell function by altering mitochondrial activity, showing antibiotic-specific immunomodulatory effects in humans and mice.

This study identifies heavy-metal-remediating bacteria in the gut microbiome of suckermouth catfish from the polluted Buriganga River, highlighting their potential for bioremediation.

The paper compares ranging and territoriality among African apes, finding that economic defendability does not fully explain interspecific variation in territorial behavior.

The paper shows that nociceptive signaling is essential for the brain to represent and replay inflammatory states using human fMRI and mouse activity mapping.

This study shows that inflammatory activation impairs microglial degradation of protein aggregates by creating a lysosomal bottleneck, without affecting their uptake.

This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.

This study identifies PSMC2 overexpression as a driver of bortezomib resistance in multiple myeloma and shows that combining p97 inhibition with bortezomib overcomes this resistance.

This paper introduces a non-equilibrium theory of sensory perception using activity flows in cortical columns, showing that small-number fluctuations are essential for effective representation.

FoXSight identifies weak binding events in crystallographic fragment screening by detecting target-specific density features in noisy electron density maps.

This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.

This study identifies structural features of Hmg2 that mediate GGPP-dependent misfolding and regulation, revealing that GGPP binding occurs in the transmembrane domain and loops in the lumenal domain transmit the response.

This study uses OPM-MEG to show 2-3 month-old infants can distinguish happy and angry prosody in natural sentences, with neural discrimination occurring 346-454 ms after sentence onset.

This study analyzes ancient U/V sex chromosomes in Polytrichaceae mosses, showing that recombination suppression has limited SDR expansion and functional degeneration despite their 124 million-year-old origin.