Aging-associated changes in transcriptional elongation influence metazoan longevity.
Cédric Debès, Antonios Papadakis, Sebastian Grönke, Özlem Karalay, Luke Stephen Tain, Athanasia Mizi, Shuhei Nakamura, Oliver Hahn, Carina Marianne Weigelt, Nataša Josipović, Anne Zirkel, Isabell Brusius, Konstantinos Sofiadis, Mantha Lamprousi, Yuxuan Lu, , Andreas Beyer
This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.
bioRxiv · Dec 5, 2022 · PreprintGenomics