A. A. Koshy

The latent stage of Toxoplasma gondii is targeted by the immune response and host protective

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

Toxoplasma type II effector GRA15 has limited influence in vivo

This study investigates the role of Toxoplasma gondii type II effector GRA15 in vivo, finding it has a limited impact on brain parasite burden and immune cell numbers at 3 weeks post-infection.

Chronic Toxoplasma gondii infection curtails the cytotoxic potential of acute T cell responses to West Nile virus in the brain.

The paper shows that chronic Toxoplasma gondii infection reduces the cytotoxic response of T cells to West Nile virus in the brain, increasing susceptibility to WNV.

ROP16-mediated activation of STAT6 facilitates encystment of type III Toxoplasma gondii in neurons

This study identifies ROP16-mediated phosphorylation of STAT6 as a host factor facilitating strain-specific encystment of Toxoplasma gondii in neurons.

Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis

This paper investigates how secondary TCR engagement affects CD8+ T cell heterogeneity during acute and chronic toxoplasmosis, showing its role in effector responses but limited impact on memory populations.

Toxoplasma gondii injected neurons localize to the cortex and striatum and have altered firing

This study identifies the localization and electrophysiological changes of Toxoplasma gondii-injected neurons in the mouse brain.