Author

J. L. Uhrlaub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 7

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:flow cytometry· 2

Frequent Co-Authors

J. Nikolich-Zugich· 4 shared C. P. Coplen· 3 shared M. Jergovic· 3 shared B. J. LaFleur· 2 shared C. M. Bradshaw· 2 shared J. Z. Nikolich· 2 shared A. A. Koshy· 1 shared A. S. Sukhina· 1 shared

Activity by Year

2019-2024 · peak 4/yr

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10 top collaborators · 15 mutual co-author links

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4 shared papersImmunology

J. Nikolich-Zugich

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7 papers

Recent·Most cited

Chronic Toxoplasma gondii infection curtails the cytotoxic potential of acute T cell responses to West Nile virus in the brain.

J. L. Uhrlaub, K. E. McGovern, E. F. Merritt, M. S. Kuhns, A. A. Koshy, J. Z. Nikolich

The paper shows that chronic Toxoplasma gondii infection reduces the cytotoxic response of T cells to West Nile virus in the brain, increasing susceptibility to WNV.

bioRxiv · Jan 21, 2024 · PreprintImmunology

Characterization of low copy number human angiotensin-convertase 2 (hACE2)-transgenic mice as an improved model of SARS-CoV-2 infection

C. M. Bradshaw, T. Georgieva, T. N. Tankersley, T. Taylor-Doyle, L. Johnson, J. L. Uhrlaub, D. Besselsen, J. Z. Nikolich

This study develops low-copy hACE2 transgenic mice to better model SARS-CoV-2 infection, showing reduced mortality and viral spread compared to high-copy lines.

bioRxiv · Aug 31, 2023 · PreprintImmunology

LIFELONG CYTOMEGALOVIRUS AND EARLY-LIFE IRRADIATION SYNERGISTICALLY POTENTIATE AGE-RELATED DEFECTS IN RESPONSE TO VACCINATION AND INFECTION

J. L. Pugh, C. P. Coplen, A. S. Sukhina, J. L. Uhrlaub, J. L. Padilla-Torres, T. Hayashi, J. Nikolich-Zugich

This study shows that lifelong cytomegalovirus and early-life irradiation together worsen age-related immune defects in response to vaccination and infection.

bioRxiv · Dec 1, 2021Immunology

The impact of murine cytomegalovirus (mCMV) route and age at infection upon virus spread, immune responses and the establishment of latency

C. P. Coplen, M. Jergovic, E. L. Terner, J. L. Uhrlaub, J. Nikolich-Zugich

This study compares the effects of infection route and age on mCMV spread, immune responses, and latency in mice, finding age-related differences in immune activation and T cell responses.

bioRxiv · Nov 29, 2021 · PreprintImmunology

Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

S. A. Sonar, J. L. Uhrlaub, C. P. Coplen, G. D. Sempowski, J. A. Dudakov, M. R. M. van den Brink, B. J. LaFleur, M. Jergovic, J. Nikolich-Zugich

This study shows that skin-draining lymph nodes atrophy early in mice, leading to impaired immune function and reduced effector cell production in older age.

bioRxiv · Nov 22, 2021Immunology

Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination

M. Jergovic, J. L. Uhrlaub, M. Watanabe, C. M. Bradshaw, L. M. White, B. J. LaFleur, T. Edwards, R. Sprissler, M. Worobey, D. Bhattacharya, J. Nikolich-Zugich

This study shows older adults have robust cellular immunity and comparable neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination.

bioRxiv · Jul 22, 2021 · PreprintImmunology

MAVS regulates the quality of the antibody response to West-Nile Virus

M. O'Ketch, C. Larson, S. Williams, J. L. Uhrlaub, R. Wong, N. R. Deshpande, D. Schenten

This study shows that MAVS, an RLR signaling adaptor, is critical for the quality of the antibody response to WNV, as MAVS-deficient mice produced low-affinity IgM antibodies despite normal antigen levels.

bioRxiv · Dec 15, 2019Immunology