S. Krug

Intact and Degenerate Diguanylate Cyclases regulate Shigella Cyclic di-GMP

This study examines the role of intact and degenerate DGCs in Shigella c-di-GMP synthesis and pathogenesis, finding that some degenerate DGCs still produce c-di-GMP despite mutations.

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis

This paper develops a DNA vaccine targeting dendritic cells that enhances isoniazid efficacy against tuberculosis by inducing strong immune responses and reducing Mtb burden.

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.

Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

This study shows that inhibiting the Integrated Stress Response (ISR) pathway alongside standard TB antibiotics reduces bacterial loads and accelerates sterilization in a mouse model of tuberculosis.

Host regulator PARP1 contributes to sex differences and immune responses in a mouse model of tuberculosis

This study identifies PARP1 as a key regulator of sex differences and immune responses in a mouse model of tuberculosis, showing it enhances early proinflammatory responses in males but impairs containment in females.

Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis

This study uses human organoids to investigate how Giardia duodenalis infection disrupts intestinal epithelial barriers, identifying early ion transport changes followed by tight junction breakdown.