Author

A. Arunagiri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Arvan· 4 shared L. Haataja· 2 shared A. Cazenave-Gassiot· 1 shared A. Ghosh· 1 shared A. Hassan· 1 shared A. Hermann· 1 shared A. Pathak· 1 shared A. Traynor-Kaplan· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCell Biology

P. Arvan

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Author profile →

4 papers

Recent·Most cited

Differential roles of beta-cell IP3R and RyR ER Ca2+ channels in ER stress-induced alterations of beta-cell Ca2+ homeostasis

I. X. Zhang, A. Hermann, J. Leon, A. Arunagiri, P. Arvan, L. Satin

This study investigates how ER stress affects IP3R and RyR Ca2+ channels in beta cells, showing RyR1 dysfunction contributes to Ca2+ dysregulation and apoptosis.

bioRxiv · Oct 11, 2022 · PreprintPhysiology

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Y.-T. Yeh, C. Sona, X. Yan, A. Pathak, M. I. McDermott, Z. Xie, L. Liu, A. Arunagiri, Y. Wang, A. Cazenave-Gassiot, A. Ghosh, F. von Meyenn, S. Kumarasamy, S. M. Najjar, S. Jia, , M. N. Poy

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

bioRxiv · Jul 6, 2022Cell Biology

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

M. Alam, A. Arunagiri, L. Haataja, M. Torres, D. Larkin, J. Kappler, N. Jin, P. Arvan

This study shows that a proinsulin mutation increases susceptibility to diet-induced diabetes in mice, with severity linked to genetic dosage and beta-cell dysfunction.

bioRxiv · Jun 1, 2021Cell Biology

Distinct states of proinsulin misfolding in MIDY

L. Haataja, A. Arunagiri, A. Hassan, K. Regan, B. Tsai, B. Dhayalan, M. A. Weiss, M. Liu, P. Arvan

The paper investigates proinsulin misfolding in MIDY mutants, showing that disrupting the Cys(A6)-Cys(A11) bond can restore proper folding and ER export in some mutants.

bioRxiv · May 10, 2021Biochemistry