A. Cazenave-Gassiot

MFSD7c functions as a transporter of choline at the blood-brain barrier

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

Mfsd7b facilitates choline uptake and missense mutations affect choline transport function

This study identifies MFSD7b as a choline transporter and shows that missense mutations impair its function.

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.

Depleting cationic lipids involved in antimicrobial resistance drives adaptive lipid remodeling in Enterococcus faecalis

This study shows that depleting cationic lipids in Enterococcus faecalis leads to adaptive lipid remodeling, including reduced PG, increased phosphorus-containing lipids, and altered fatty acid metabolism.

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis

The paper shows that diacylglycerol (DG) depletion from the inner nuclear membrane during mitosis in fission yeast drives nuclear envelope expansion through DG-to-PA conversion and glycerophospholipid synthesis.

The composition and function of Enterococcus faecalismembrane vesicles

This study identifies and functionally characterizes membrane vesicles from Enterococcus faecalis, revealing unique lipid and protein profiles and their potential role in virulence.

FasR regulates fatty acid biosynthesis and is essential for virulence of Mycobacterium tuberculosis

This study identifies FasR as a regulator of lipid metabolism in Mycobacterium tuberculosis, showing its essential role in virulence and immune evasion.