Author

L. Desmarets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

S. Belouzard· 4 shared J. Dubuisson· 3 shared K. Seron· 3 shared Y. Rouille· 3 shared C. Robil· 2 shared F. Trottein· 2 shared N. Francois· 2 shared S. Sahpaz· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

S. Belouzard

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses

I. Raczkiewicz, C. Riviere, P. Bouquet, L. Desmarets, A. Tarricone, C. Camuzet, N. Francois, G. Lefevre, J. Samaillie, F. Silva Angulo, C. Robil, F. Trottein, S. Sahpaz, J. D. Dubuisson, S. Belouzard, , K. Seron

This study shows that hyperforin from Hypericum perforatum inhibits multiple coronaviruses, including SARS-CoV-2, with antiviral activity confirmed in human cells and potential for combination therapy with remdesivir.

bioRxiv · Apr 9, 2024 · PreprintMicrobiology

A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses

T. Meunier, L. Desmarets, S. Bordage, M. Bamba, K. Hervouet, Y. Rouille, N. Francois, M. Decossas, F. H. Tra Bi, O. Lambert, J. Dubuisson, S. Belouzard, S. Sahpaz, K. Seron

This paper identifies pheophorbide a as a light-activated natural antiviral effective against SARS-CoV-2, MERS-CoV, and other enveloped viruses by inhibiting viral entry and replication.

bioRxiv · Jul 9, 2021Microbiology

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

S. Belouzard, A. Machelart, V. Sencio, T. Vausselin, E. Hoffmann, N. Deboosere, Y. Rouille, L. Desmarets, K. Seron, A. Danneels, C. Robil, L. Belloy, C. Moreau, C. Piveteau, A. Biela, , J. Dubuisson

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

bioRxiv · Jun 30, 2021 · PreprintMicrobiology

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

A. Rebendenne, P. Roy, B. Bonaventure, A. L. Chaves Valadao, L. Desmarets, Y. Rouille, M. Tauziet, M. Arnaud-Arnould, D. Giovannini, Y. Lee, P. DeWeirdt, M. Hegde, F. Garcia de Gracia, J. McKellar, M. Wencker, , C. Goujon

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

bioRxiv · May 19, 2021Microbiology