Author

Y. Rouille

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 1 Assay:electronic health records· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

J. Dubuisson· 7 shared K. Hervouet· 4 shared K. Seron· 4 shared P. Brodin· 4 shared A. Vandeputte· 3 shared C. Camuzet· 3 shared C. Montpellier· 3 shared L. Cocquerel· 3 shared

Activity by Year

2018-2021 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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7 shared papersMicrobiology

J. Dubuisson

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Author profile →

8 papers

Recent·Most cited

Characterization of the hepatitis E virus replicase

K. Metzger, B. Cyrine, K. Hervouet, V. Alexandre, C. Montpellier, J. M. Saliou, M. Ferrie, C. Camuzet, Y. Rouille, C. Lecoeur, J. Dubuisson, L. Cocquerel, C. M. Aliouat Denis

This study characterizes the hepatitis E virus replicase by inserting V5 epitopes into ORF1 and identifying its localization and processing during replication.

bioRxiv · Dec 3, 2021Microbiology

The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus

C. Bentaleb, K. Hervouet, C. Montpellier, C. Camuzet, M. Ferrie, J. Burlaud-Gaillard, S. Bressanelli, K. Metzger, E. Werkmeister, M. Ankavay, N. L. Janampa, J. Marlet, J. Roux, C. Deffaud, A. Goffard, , L. Cocquerel

This study identifies the endocytic recycling compartment as a site where HEV forms membrane networks, revealing a novel viral factory structure.

bioRxiv · Oct 14, 2021Microbiology

A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses

T. Meunier, L. Desmarets, S. Bordage, M. Bamba, K. Hervouet, Y. Rouille, N. Francois, M. Decossas, F. H. Tra Bi, O. Lambert, J. Dubuisson, S. Belouzard, S. Sahpaz, K. Seron

This paper identifies pheophorbide a as a light-activated natural antiviral effective against SARS-CoV-2, MERS-CoV, and other enveloped viruses by inhibiting viral entry and replication.

bioRxiv · Jul 9, 2021Microbiology

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

S. Belouzard, A. Machelart, V. Sencio, T. Vausselin, E. Hoffmann, N. Deboosere, Y. Rouille, L. Desmarets, K. Seron, A. Danneels, C. Robil, L. Belloy, C. Moreau, C. Piveteau, A. Biela, , J. Dubuisson

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

bioRxiv · Jun 30, 2021 · PreprintMicrobiology

An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host Cell

K. Hervouet, M. Ferrie, M. Ankavay, C. Montpellier, C. Camuzet, V. Alexandre, A. Dembele, C. Lecoeur, A. T. Foe, P. Bouquet, D. Hot, T. Vausselin, J.-M. Saliou, S. Salome-Desnoulez, L. Marsollier, , L. Cocquerel

This study identifies an Arginine-Rich Motif in the HEV ORF2 capsid protein that regulates its subcellular localization, functionality, and interactions with host cells, revealing its central role in the HEV lifecycle.

bioRxiv · May 26, 2021Microbiology

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

A. Rebendenne, P. Roy, B. Bonaventure, A. L. Chaves Valadao, L. Desmarets, Y. Rouille, M. Tauziet, M. Arnaud-Arnould, D. Giovannini, Y. Lee, P. DeWeirdt, M. Hegde, F. Garcia de Gracia, J. McKellar, M. Wencker, , C. Goujon

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

bioRxiv · May 19, 2021Microbiology

Dehydrojuncusol, a Natural Phenanthrene Compound Extracted from Juncus maritimus Is a New Inhibitor of Hepatitis C Virus Replication

M.-E. Sahuc, R. Sahli, C. Riviere, V. Pene, M. Lavie, A. Vandeputte, P. Brodin, A. Rosenberg, J. D. Dubuisson, R. Ksouri, Y. Rouille, S. Sahpaz, K. Seron

This paper identifies dehydrojuncusol, a natural compound from Juncus maritimus, as a new inhibitor of HCV replication that targets NS5A and is effective against DAA-resistant variants.

bioRxiv · Nov 14, 2018Microbiology

Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus

P. Chowdhury, M.-E. Sahuc, Y. Rouille, A. Vandeputte, P. Brodin, M. Goswami, T. Bandyopadhyay, J. Dubuisson, K. Seron

This study shows that theaflavins from black tea inhibit HCV entry in a dose-dependent manner and show additive effects with existing antivirals.

bioRxiv · May 17, 2018Microbiology