Author

A. Vannini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:chromatin & epigenetic regulation· 7 Organism:human· 5 Research Focus:cell type annotation· 3 Approach:genetic perturbation / CRISPR· 3 Assay:structural biology· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

E. Cutts· 4 shared C. Engel· 3 shared F. Beuron· 3 shared G. Abascal-Palacios· 3 shared A. Musacchio· 2 shared D. Pan· 2 shared E. Morris· 2 shared F. B. Heiss· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCell Biology

E. Cutts

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Condensin II activation by M18BP1

A. Borsellini, D. Conti, E. Cutts, R. J. Harris, K. Walstein, A. Graziadei, V. Cecatiello, T. F. Aarts, R. Xie, A. Mazouzi, S. Sen, C. Hoencamp, R. Pleuger, S. Ghetti, L. Oberste-Lehn, , A. Vannini

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

bioRxiv · May 2, 2024Cell Biology

The human RNA polymerase I structure reveals an HMG-like transcription factor docking domain specific to metazoans

J. L. Daiss, M. Pilsl, K. Straub, A. Bleckmann, M. Höcherl, F. B. Heiss, G. Abascal-Palacios, E. Ramsay, K. Tluckova, J.-C. Mars, A. Bruckmann, C. Bernecky, V. Lamour, K. Panov, A. Vannini, , C. Engel

The paper determines the structure of human RNA polymerase I, identifies a novel HMG-like domain in RPA1, and shows its role in recruiting Topoisomerase 2a and UBF for transcription regulation.

bioRxiv · Dec 22, 2021 · PreprintBiochemistry

Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes

G. Abascal-Palacios, L. Jochem, C. Pla-Prats, F. Beuron, A. Vannini

This paper presents a cryo-EM structure of the Ty3 retrotransposon integration complex bound to RNA Polymerase III transcription factors, revealing mechanisms of specific integration at tRNA genes.

bioRxiv · Jul 27, 2021Biophysics

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface.

M. Houlard, E. Cutts, M. S. Shamim, J. Godwin, D. Weisz, A. Presser Aiden, E. Lieberman Aiden, L. Schermelleh, A. Vannini, K. Nasmyth

This paper shows MCPH1 inhibits condensin II during interphase by binding to NCAPG2, preventing chromosome condensation, and demonstrates that this regulation is essential for maintaining chromatin structure.

bioRxiv · Jul 20, 2021Cell Biology

Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

P. Choppakatla, B. Dekker, E. Cutts, A. Vannini, J. Dekker, H. Funabiki

This study shows H1.8 inhibits condensins and topo II to regulate chromosome length and individualization during mitosis.

bioRxiv · Dec 20, 2020Cell Biology

A commercial antibody to the human condensin II subunit NCAPH2 cross-reacts with a SWI/SNF complex component

E. E. Cutts, G. C. Taylor, M. Pardo, L. Yu, J. Wills, J. S. Choudhary, A. Vannini, A. J. Wood

The paper identifies cross-reactivity of a commercial NCAPH2 antibody with SWI/SNF complex components, affecting immunoprecipitation experiments.

bioRxiv · Nov 7, 2020Cell Biology

Structure of human RNA Polymerase III

E. P. Ramsay, G. Abascal-Palacios, J. L. Daiss, H. King, J. Gouge, M. Pilsl, F. Beuron, E. Morris, P. Gunkel, C. Engel, A. Vannini

The paper determines the structure of human RNA Polymerase III using cryo-EM and maps mutations linked to neurodevelopmental disorders and viral hypersensitivity.

bioRxiv · Jun 29, 2020 · PreprintBiochemistry

DNA origami-based single-molecule force spectroscopy unravels the molecular basis of RNA Polymerase III pre-initiation complex stability

K. Kramm, T. Schroeder, J. Gouge, A. M. Vera, F. B. Heiss, T. Liedl, C. Engel, A. Vannini, P. Tinnefeld, D. Grohmann

The paper uses DNA origami force clamps to study how force affects initiation complex stability in RNA polymerase II and III systems, revealing Bdp1's critical role in RNAP III stability.

bioRxiv · Sep 19, 2019 · PreprintBiophysics

Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA

M. Kong, E. Cutts, D. Pan, F. Beuron, T. Kaliyappan, C. Xue, E. Morris, A. Musacchio, A. Vannini, E. Greene

This study shows human condensin I and II compact nucleosome-bound DNA through ATP-dependent motor activity, forming reversible DNA loops without displacing nucleosomes.

bioRxiv · Jun 27, 2019Biochemistry