R. Xie

Condensin II activation by M18BP1

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

Targeted NAD+ Delivery for Intimal Hyperplasia and Re-endothelialization: A Novel Anti-restenotic Therapy Approach

This study demonstrates that targeted NAD+ delivery via nanocarriers reduces intimal hyperplasia and promotes endothelial regeneration in a rat model of restenosis.

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

Droplet bioprinting of acellular and cell-laden structures at high-resolutions

This paper introduces a droplet bioprinting method that prints 3D soft structures at high resolution with high cell viability and functionality.

O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Meniscus-enabled Projection Stereolithography (MAPS)

This paper introduces MAPS, a new 3D printing method that enables multi-material printing with minimal cross-contamination and waste.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

HEXOKINASE-dependent regulation of WRKY transcription factors in Arabidopsis

The paper identifies four WRKY transcription factors upregulated by sugar via a superoxide signaling pathway dependent on hexokinase 1, suggesting a role in plant growth regulation.

The episodic resurgence of highly pathogenic avian influenza H5 virus

This study tracks the resurgence of H5N1 avian influenza, identifying key events and genetic changes that contributed to its global spread from 2016/17 to 2021/22.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Combinatorial perturbation sequencing on single cells using microwell-based droplet random pairing

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

Real-time feeding behavior monitoring by electrical penetration graph rapidly reveals host plant susceptibility to crapemyrtle bark scale (Hemiptera: Eriococcidae)

This paper develops an EPG-based method to rapidly assess plant susceptibility to crapemyrtle bark scale by analyzing real-time feeding behavior parameters.

Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)

This study confirms that larval green lacewing Chrysoperla rufilabris preys on crapemyrtle bark scale at different life stages and shows its potential as a biological control agent.

A connectivity signature for glioblastoma

This paper establishes and validates a connectivity signature in glioblastoma using scRNA-Seq data, showing high connectivity correlates with poor patient survival and specific molecular subtypes.

Expanding Asgard members in the domain of Archaea shed new light on the origin of eukaryotes

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports the origin of eukaryotes within Archaea.

Expanded Asgard archaea shed new light on the origin of eukaryotes and support a 2-domain tree of life

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

The paper identifies effectors from plant pathogens that specifically target subsets of NRC immune receptor proteins, revealing convergent strategies to counteract redundant nodes in the NLR network.

Imaging transmembrane dynamics of biomolecules at live cell plasma membranes using quenchers in extracellular environment

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

The paper identifies specific target proteins bound by WW domain tandems of KIBRA and MAGI with high affinity and specificity, revealing new binding partners and mechanisms.

VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression

This study shows that VPAC1 and TRPV4 channel interaction promotes calcium-dependent gastric cancer progression through a positive feedback loop involving VIP secretion.