Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation
N. Rodrigues Mantuano, M. A. Stanczak, I. de Araujo Oliveira, N. Kirchhammer, A. Filardy, G. Monaco, R. C. Santos, A. Carlos Fonseca, M. Fontes, C. de Souza Bastos, W. B. Dias, A. Zippelius, A. R. Todeschini, H. Laubli
This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.
bioRxiv · Nov 5, 2019Cancer Biology