H. Xue

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers

This paper identifies m-APTA, an MTA analogue that reduces NBA toxicity without hypothermia, improving safety for MTAP-deficient cancer treatment.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

In sickness and in health: RNA-Seq finds viruses associated with mutualist quality in the Amazonian plant-ant Allomerus octoarticulatus

The paper uses RNA-Seq to identify viruses associated with variation in defensive behavior of ant-plant mutualists in the Amazon.

Genomic evidence for supergene control of Darwin's 'complex marriage arrangement' - the tristylous floral polymorphism

The paper identifies two supergenes controlling tristyly in Eichhornia paniculata, with specific gene expression patterns and evolutionary age estimates supporting their role in the polymorphism.

Powdery mildew infection induces a non-canonical route to storage lipid formation at the expense of host thylakoid lipids to fuel its spore production

This study shows powdery mildew infection causes plant thylakoid lipid breakdown to produce storage lipids for fungal spore production, involving DGAT3 in chloroplasts.

Development of an Accelerated Cellular Model for Alzheimer's Disease

This study uses progerin to accelerate AD phenotypes in neural progenitor cells with FAD mutations, showing increased tau phosphorylation, amyloid plaques, and cell death within weeks.

A toxic ankyrin cysteine protease effector RipBH of brown rot triggered autophagy-associated cell death

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

Ralstonia solanacearum alters root developmental programs in auxin-dependent and independent manners

This study shows Ralstonia solanacearum alters root development in Arabidopsis through auxin-dependent and independent mechanisms, including promoting xylem differentiation and root hair formation.

Locally restricted glucose availability in the embryonic hypocotyl determines seed germination under ABA treatment

The paper shows ABA treatment restricts glucose availability in the embryonic hypocotyl, affecting seed germination through altered sugar partitioning and metabolism.

A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease

This study identifies a metabolic pathway involving pyruvate decarboxylases that contributes to plant resistance against bacterial wilt disease, and shows how a bacterial effector inhibits this pathway to promote disease.

Telmisartan potentiates insulin secretion via ion channels, independent of the AT1 receptor and PPARγ

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

An ectosymbiosis-based mechanism of eukaryogenesis

This paper proposes an ectosymbiosis-based mechanism for eukaryogenesis, identifying specific prokaryotic contributors and showing a decrease in prokaryote-derived gene ratios from Microsporidia to mitochondriate eukaryotes.

A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity

This study identifies RipAC, a bacterial effector that inhibits SGT1 phosphorylation by blocking its interaction with MAPKs, thereby suppressing plant immunity.

Descent of Bacteria and Eukarya from an archaeal root of life

The paper investigates the evolutionary origins of Bacteria, Eukarya, and Archaea by analyzing gene homologies and proposes an archaeal root of life.

The receptor-like kinases BAM1 and BAM2 promote the cell-to-cell movement of miRNA in the root stele to regulate xylem patterning

The paper shows BAM1 and BAM2 kinases facilitate miR165/6 movement through plasmodesmata, regulating xylem patterning in the root.

BAP1 Haploinsufficiency Predicts a Distinct Immunogenic Class of Malignant Peritoneal Mesothelioma

The paper identifies BAP1 loss as a marker for a distinct immunogenic PeM subtype, suggesting potential therapeutic targets like immune checkpoint inhibitors.

MiR-126 impairs the intestinal barrier function via inhibiting S1PR2 mediated activation of PI3K/AKT signaling pathway

This study shows miR-126 reduces S1PR2 expression, inhibits PI3K/AKT signaling, and impairs intestinal barrier function in IBD.