Author

L. Thorley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:chicken / avian· 1 Assay:CUT&Tag· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Berg· 1 shared A. D. Douglas· 1 shared A. Sims· 1 shared B. H. Thompson· 1 shared C. Boutell· 1 shared C. Loney· 1 shared C. Perillo· 1 shared C. Sharp· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMicrobiology

A. Berg

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Superinfection exclusion creates spatially distinct influenza virus populations

A. Sims, L. B. Tornaletti, S. Jasim, C. Perillo, R. Devlin, J. Hirst, C. Loney, J. Wojtus, E. Sloan, L. Thorley, C. Boutell, E. Roberts, E. Hutchinson

This study shows that superinfection exclusion (SIE) creates spatially distinct influenza virus populations, limiting genome interactions between virus subpopulations as they spread within host tissues.

bioRxiv · Jun 6, 2022Microbiology

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

C. Sharp, B. H. Thompson, T. J. Nash, O. Lee, R. M. Pinto, L. Thorley, Y.-T. Lin, S. Sives, H. Wise, S. M. R. Clohisey, F. Grey, L. Vervelde, P. Simmonds, P. Digard, E. R. Gaunt

This paper engineers an influenza A virus with increased CpG content, showing it is attenuated in mice but replication competent in vaccine propagation systems, suggesting a new strategy for live attenuated vaccines.

bioRxiv · Apr 29, 2022Microbiology

Structure of trimeric pre-fusion rabies virus glycoprotein in complex with two protective antibodies

W. M. Ng, S. Fedosyuk, S. English, G. Augusto, A. Berg, L. Thorley, R. R. Segireddy, T. A. Bowden, A. D. Douglas

The paper reports the structure of pre-fusion rabies virus glycoprotein complexed with two protective antibodies, showing how they stabilize the protein and provide insights for vaccine design.

bioRxiv · Feb 28, 2022Microbiology