R. Robinson

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Dispersal syndromes allow understanding but not predicting dispersal ability across the tree of life.

The paper investigates dispersal syndromes in European birds, finding that body mass and life history traits predict dispersal, but syndromes are poor predictors for phylogenetically distant species.

Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

This study shows that gasdermin D promotes influenza virus-induced mortality by amplifying neutrophil-driven inflammation.

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

The paper shows Mtb-infected mice are resistant to secondary SARS-CoV-2 infection without affecting Mtb levels, linked to T and B cell expansion in the lungs.

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

Opposing activities of IFITM proteins in SARS-CoV-2 infection

This study identifies opposing roles of IFITM3 in restricting and enhancing SARS-CoV-2 infection through distinct mechanisms involving endosomal restriction and plasma membrane fusion.

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signalling

The paper investigates how extracellular domains of E-cadherin influence epithelial mechanical properties through cell- and non-cell-autonomous signaling.

Pneumococcal Colonisation is an Asymptomatic Event in Healthy Adults using an Experimental Human Colonisation Model.

This study investigates whether pneumococcal colonisation in healthy adults is symptomatic using an experimental challenge model, finding it asymptomatic regardless of bacterial density or viral co-colonisation.

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.