Author

A. C. Koong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Giaccia· 2 shared D. Jiang· 2 shared E. E. Graves· 2 shared A. Babic· 1 shared A. Bhutkar· 1 shared A. Blondel· 1 shared A. Dias Costa· 1 shared A. Diep· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. J. Giaccia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Developing High-Affinity Decoy Receptor Optimized for Multiple Myeloma and Diffuse Large B Cell Lymphoma Treatment

Y. R. Miao, K. Thakkar, C. Cenik, D. Jiang, K. Mizuno, C. Jia, G. C. Li, H. Zhao, A. Diep, J. Y. Xu, X. E. Zhang, T. T. C. Yang, M. Liedtke, P. Abidi, W.-s. Leung, , A. J. Giaccia

This paper develops an engineered sBCMA-Fc fusion protein with enhanced binding affinity to APRIL and BAFF, showing improved antitumor activity against multiple myeloma and diffuse large B cell lymphoma in preclinical models.

bioRxiv · May 3, 2021Cancer Biology

Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

A. Papaioannou, F. G. Centonze, A. Metais, M. Maurel, L. Negroni, M. Gonzales-Quiroz, E. Zare Golchesmeh, A. Blondel, A. C. Koong, C. Hetz, R. Pedeux, M. L. Tremblay, S. J. Mahdizadeh, G. Svensson, L. A. Eriksson, e. chevet

This study identifies RtcB tyrosine phosphorylation as a regulatory mechanism controlling IRE1's dual RNase activities, influencing cell survival or death during ER stress.

bioRxiv · Mar 2, 2020Biochemistry

FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

K. Levy, S. Natarajan, J. Wang, S. Chow, J. T. Eggold, P. Loo, R. Manjappa, F. M. Lartey, E. Schüler, L. Skinner, M. Rafat, R. Ko, A. Kim, D. Al Rawi, R. von Eyben, , E. B. Rankin

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

bioRxiv · Dec 12, 2019 · PreprintCancer Biology

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

K. M. Chung, J. Singh, L. Lawres, K. J. Dorans, C. Garcia, D. B. Burkhardt, R. Robbins, A. Bhutkar, R. Cardone, X. Zhao, A. Babic, S. A. Vayrynen, A. Dias Costa, J. A. Nowak, D. T. Chang, , M. D. Muzumdar

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

bioRxiv · Sep 26, 2019Cancer Biology