Author

G. C. Russo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:cell-cell communication· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. Wirtz· 6 shared A. J. Crawford· 4 shared M.-H. Lee· 3 shared P.-H. Wu· 3 shared A. Kiemen· 2 shared A. Munoz-Barrutia· 2 shared I. Bhorkar· 2 shared I.-M. Shih· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersCancer Biology

D. Wirtz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Small extracellular vesicles promote stiffness-mediated metastasis

A. Sneider, Y. Liu, B. Starich, W. Du, C. Marar, N. Faqih, G. E. Ciotti, J. H. Kim, S. Krishnan, S. Ibrahim, M. Igboko, A. Locke, D. M. Lewis, H. Hong, M. Karl, , D. Wirtz

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

bioRxiv · Jul 1, 2023Cancer Biology

Precision-engineered biomimetics: the human fallopian tube

A. J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G. C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, , D. Wirtz

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

bioRxiv · Jun 6, 2023 · PreprintBioengineering

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

G. Lee, C. Wong, A. Cho, J. J. West, A. J. Crawford, G. C. Russo, B. R. Si, J. Kim, L. Hoffner, C. Jang, M. Jung, R. D. Leone, K. Konstantopoulos, A. J. Ewald, D. Wirtz, S. Jeong

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

bioRxiv · May 24, 2023 · PreprintCancer Biology

Tumor proliferation and invasion are coupled through cell-extracellular matrix friction

A. J. Crawford, C. Gomez-Cruz, G. C. Russo, W. Huang, I. Bhorkar, A. Munoz-Barrutia, D. Wirtz, D. Garcia-Gonzalez

This study shows tumor proliferation and invasion are linked through cell-ECM friction, using in vitro and computational models to demonstrate the role of E-cadherin and matrix properties.

bioRxiv · Nov 15, 2022 · PreprintBiophysics

E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

G. C. Russo, A. J. Crawford, D. J. Clark, J. Cui, R. Carney, M. N. Karl, B. Su, B. A. Starich, T.-S. Lih, P. Kamat, Q. Zhang, P.-h. Wu, M.-H. Lee, H. S. Leong, V. W. Rebecca, , D. Wirtz

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

bioRxiv · Nov 4, 2020Cancer Biology

Multi-compartment tumor organoids

M.-H. Lee, Y. S. Rahmanto, G. C. Russo, P.-h. Wu, D. Gilkes, A. Kiemen, T. Miyamoto, Y. Yu, M. Habibi, I.-M. Shih, T.-L. Wang, D. Wirtz

This paper develops a high-throughput microtechnology to create multi-compartment tumor organoids that mimic tumor microenvironments and improve drug response and tumor progression studies.

bioRxiv · Nov 3, 2020Cancer Biology