Author

M.-H. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 3 Bioengineering· 1 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Assay:organoid / primary culture· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

D. Wirtz· 3 shared G. C. Russo· 3 shared P.-H. Wu· 3 shared A. J. Crawford· 2 shared A. Kiemen· 2 shared B. Kang· 2 shared C. Kim· 2 shared D.-K. Ryu· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCancer Biology

D. Wirtz

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Precision-engineered biomimetics: the human fallopian tube

A. J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G. C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, , D. Wirtz

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

bioRxiv · Jun 6, 2023 · PreprintBioengineering

Non-Invasive Cancer Detection in Canine Urine through C. elegans Chemotaxis

C. Namgong, J. H. Kim, M.-H. Lee, D. Midkiff

This study demonstrates a non-invasive cancer detection method using C. elegans chemotaxis to canine urine, achieving 85% sensitivity and 93% specificity for common canine cancers.

bioRxiv · Apr 29, 2022 · PreprintCancer Biology

The in vitro and in vivo potency of CT-P59 against Delta and its associated variants of SARS-CoV-2

D.-K. Ryu, H.-M. Woo, B. Kang, H. Noh, J.-I. Kim, J.-M. Seo, C. Kim, M. Kim, J.-W. Kim, N. Kim, P. Jeon, H. Lee, J.-S. Yang, K.-C. Kim, J.-Y. Lee, , S.-Y. Lee

This study evaluates CT-P59's antiviral activity against Delta and its variants, showing reduced in vitro potency but effective in vivo neutralization and symptom remission in mice.

bioRxiv · Jul 23, 2021 · PreprintMicrobiology

Therapeutic efficacy of CT-P59 against P.1 variant of SARS-CoV-2

S.-Y. Lee, D.-K. Ryu, b. Kang, H. Noh, J. Kim, J.-M. Seo, C. Kim, C. v. Baalen, A. S. Tijsma, H.-Y. Chung, M.-H. Lee, S.-S. Oh, J.-a. Choi, M. Song, K.-S. Kwon

This study evaluates CT-P59's efficacy against the P.1 SARS-CoV-2 variant through in vitro and in vivo tests, showing reduced in vitro neutralization but therapeutic benefit in mice.

bioRxiv · Jul 8, 2021 · PreprintMicrobiology

Ovulation sources coagulation protease cascade and hepatocyte growth factor to support physiological growth and malignant transformation

H.-S. Huang, P.-C. Chen, S.-C. Chu, M.-H. Lee, C.-Y. Huang, T.-Y. Chu

This paper identifies the coagulation protease cascade and hepatocyte growth factor (HGF) as mediators of sustained transformation activity from ovulation, promoting both physiological repair and malignant transformation of ovarian tissues.

bioRxiv · Jun 16, 2021Cancer Biology

Simeprevir suppresses SARS-CoV-2 replication and synergizes with remdesivir

H. S. Lo, K. P. Y. Hui, H.-M. Lai, K. S. Khan, S. Kaur, J. Huang, Z. Li, A. K. N. Chan, H. H.-Y. Cheung, K. C. Ng, J. C. W. Ho, Y. W. Chen, B. Ma, P. M.-H. Cheung, D. Shin, , W.-L. Ng

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

ACS Central Science · Apr 15, 2021Peer-reviewedMicrobiology

The Arabidopsis ORA59 coordinates jasmonic acid- and ethylene-responsive gene expression to regulate plant immunity

Y. N. Yang, Y. Kim, H. Kim, S. J. Kim, K.-M. Cho, Y. Kim, D. S. Lee, M.-H. Lee, S. Y. Kim, J. C. Hong, S. J. Kwon, J. Choi, O. K. Park

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

bioRxiv · Mar 16, 2021 · PreprintPlant Biology

E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

G. C. Russo, A. J. Crawford, D. J. Clark, J. Cui, R. Carney, M. N. Karl, B. Su, B. A. Starich, T.-S. Lih, P. Kamat, Q. Zhang, P.-h. Wu, M.-H. Lee, H. S. Leong, V. W. Rebecca, , D. Wirtz

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

bioRxiv · Nov 4, 2020Cancer Biology

Multi-compartment tumor organoids

M.-H. Lee, Y. S. Rahmanto, G. C. Russo, P.-h. Wu, D. Gilkes, A. Kiemen, T. Miyamoto, Y. Yu, M. Habibi, I.-M. Shih, T.-L. Wang, D. Wirtz

This paper develops a high-throughput microtechnology to create multi-compartment tumor organoids that mimic tumor microenvironments and improve drug response and tumor progression studies.

bioRxiv · Nov 3, 2020Cancer Biology

IFN-{lambda}4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

O. O. Onabajo, F. Wang, M.-H. Lee, O. Florez-Vargas, A. Obajemu, M. A. A. Castro, C. Tanikawa, J. Vargas, S.-F. Liao, C. Song, Y.-H. Huang, C.-Y. Shen, A. R. Banday, T. R. O'Brien, Z. Hu, , L. Prokunina-Olsson

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

bioRxiv · Oct 28, 2020 · PreprintCancer Biology

Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms

E. Ghosh, H. Dwivedi, M. Baidya, A. Srivastava, P. Kumari, T. Stepniewski, H. R. Kim, M.-H. Lee, J. v. Gastel, M. Chaturvedi, D. Roy, S. Pandey, J. Maharana, R. Guixa-Gonzalez, L. M. Luttrell, , A. K. Shukla

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

bioRxiv · Aug 5, 2019Biophysics