Author

B. van den Broek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. Jalink· 3 shared B. Morris· 2 shared C. Lieftink· 2 shared F. M. Feringa· 2 shared J. Jonkers· 2 shared J. Klarenbeek· 2 shared L. Koob· 2 shared L. Krenning· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

K. Jalink

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Radical differences between two FLIM microscopes affect interpretation of cell signaling dynamics

S. Mukherjee, J. Klarenbeek, F. El Oualid, B. van den Broek, K. Jalink

This study compares two FLIM microscopes and finds that differences in cAMP kinetics are due to phototoxicity from FluoroBrite medium, not the imaging technique itself.

iScience · Jul 1, 2024Peer-reviewedCell Biology

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

J. Bhin, M. Paes Dias, E. Gogola, F. Rolfs, S. R. Piersma, R. de Bruijn, J. de Ruiter, B. van den Broek, A. Duarte, W. Sol, I. van der Heijden, L. Bakker, T. S. Kaiponen, C. Lieftink, B. Morris, , J. Jonkers

bioRxiv · Sep 7, 2022Cancer Biology

MND1 enables repair of two-ended DNA double-strand breaks

L. Koob, A. Friskes, L. van Bergen, F. M. Feringa, B. van den Broek, E. S. Koeleman, M. Schubert, V. A. Blomen, T. R. Brummelkamp, L. Krenning, R. H. Medema

This study shows MND1 facilitates repair of two-ended DNA double-strand breaks in somatic cells through homologous recombination, but not one-ended breaks, and its absence increases IR-induced toxicity.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

DNA end-resection in highly accessible chromatin produces a toxic break

J. van den Berg, S. E. P. Joosten, Y. Kim, A. G. Manjon, L. Krenning, L. Koob, F. M. Feringa, R. Klompmaker, B. van den Broek, K. Jalink, W. Zwart, R. H. Medema

The authors withdrew their manuscript due to inconsistencies in data and questionable experimental results regarding DNA end-resection and chromatin accessibility.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Dynamic FRET-FLIM based screens of signal transduction pathways: a feasibility study

R. Harkes, O. Kukk, S. Mukherjee, J. Klarenbeek, B. van den Broek, K. Jalink

The paper demonstrates a FRET-FLIM platform for analyzing cAMP dynamics in HeLa cells, finding that PDE3A and PDE10A significantly slow cAMP decay.

bioRxiv · May 23, 2021Cell Biology

Glucocorticoids regulate cancer cell dormancy

S. Prekovic, K. Schuurman, A. Gonzalez Manjon, M. Buijs, I. Mayayo Peralta, M. D. Wellenstein, S. Yavuz, A. Barrera, K. Monkhorst, A. Huber, B. Morris, C. Lieftink, J. Silva, B. Györffy, L. Hoekman, , W. Zwart

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.

bioRxiv · Sep 4, 2019 · PreprintCancer Biology