A. Gonzalez

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

GPCRmd provides an online platform for visualizing and analyzing GPCR molecular dynamics simulations, demonstrating its utility through analyses of internal water networks and sodium ion interactions.

The paper shows nutrient additions destabilize ecosystems by causing competitive exclusion and propagating instabilities across landscapes, exacerbated by human-driven ecological connectivity.

This study examines how freshwater bacterioplankton communities respond to agricultural stressors in mesocosms, finding that only high glyphosate doses alter community structure while functional redundancy persists.

The paper identifies PSMD14 as a regulator of Golgi-to-ER retrograde transport and macroautophagy through its role in K63-Ub chain deubiquitination.

The paper shows that prior exposure to acidification helps maintain diurnal dissolved oxygen cycles during severe acidification in aquatic mesocosms.

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

The paper assesses global human impacts on animal genetic diversity using mitochondrial sequences and land use data, finding mixed trends and strong latitude effects in some taxa.

This paper explores microbial biogeography in the human mouth, linking spatial patterns to periodontal diseases and proposing methods to test hypotheses about subgingival microbiota variation.

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

This study shows that prior exposure to sublethal stress, not community biomass, enhances evolutionary rescue in phytoplankton communities exposed to glyphosate.

The paper investigates whether natural selection targets thermal acclimation capacity in a four-eyed frog population by analyzing survival in relation to thermal trait plasticity.

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.

This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.

The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.