A. Guenther

Pre-clinical proof-of-concept of anti-fibrotic activity of caveolin-1 scaffolding domain peptide LTI-03 in ex vivo precision cut lung slices from patients with Idiopathic Pulmonary Fibrosis

This study evaluates the anti-fibrotic effects of LTI-03 in IPF patient-derived precision cut lung slices, showing dose-dependent reduction of fibrotic markers.

Collagen Tubular Airway-on-Chip for Extended Epithelial Culture andInvestigation of Ventilation Dynamics

This paper introduces a collagen tube-based airway-on-chip model that supports two-week epithelial culture and studies ventilation dynamics under physiological conditions.

Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

Deep learning accurately quantifies plasma cell percentages on CD138-stained bone marrow samples

This paper develops a deep learning model to quantify plasma cell percentages in CD138-stained bone marrow samples, achieving high accuracy comparable to pathologists.

Winners and losers over 35 years of dragonfly and damselfly distributional change in Germany

The paper analyzes 35 years of dragonfly and damselfly distributional changes in Germany using citizen science data, finding mixed trends linked to climate change and habitat loss.

Rewetting of three drained peatlands drives congruent compositional changes in pro- and eukaryotic soil microbiomes through environmental filtering

The paper examines how rewetting drained peatlands affects pro- and eukaryotic soil microbiomes, identifying soil moisture and salinity as key drivers of community composition changes.

Eukaryotic rather than prokaryotic microbiomes change over seasons in rewetted fen peatlands

This study shows that eukaryotic microbiomes, not prokaryotic, change seasonally in rewetted fen peatlands, with distinct network structures and dynamics across fen types.

Natural copy number differences of tandemly repeated small nucleolar RNAs in the Prader-Willi syndrome genomic region regulate individual behavioral responses in mammals

The paper shows that copy number variations of SNORD115 and SNORD116 in the PWS region correlate with anxiety-like behaviors across species and populations.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.