S. Bellusci

Lineage-tracing of Acta2+ cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblasts to myofibroblast reversible switch

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch

This study uses WI-38 cells to investigate the reversible switch between myofibroblast and lipofibroblast phenotypes in lung fibrosis, showing similar transcriptomic responses to treatments and supporting the LIF-MYF switch.

Postnatal FGFR-signalling establishes gradients of cell identities along the proximal-distal axis of the lung airways

The paper identifies gene-expression gradients along the lung airway axis and shows FGFR-signaling establishes these gradients postnatally.

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

This study compares transcriptomic changes in pulmonary capillary endothelial cells from young and aged mice after lung injury, finding age-related differences in resolution and fibrotic signatures.

FGF10 triggers de novo alveologenesis in a BPD model: impact on the resident mesenchymal niche cells

This study shows that FGF10 administration rescues alveologenesis defects in a BPD mouse model by activating resident mesenchymal niche cells.

Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

Identification a novel subset of alveolar type 2 cells expanding following pneumonectomy and enriched in PD-L1

The paper identifies a novel subset of quiescent alveolar type 2 cells in mice that expand after pneumonectomy and are enriched in PD-L1, with similar findings observed in human lungs.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.

Metformin induces lipogenic differentiation in myofibroblasts to reverse mouse and human lung fibrosis

This study shows metformin reduces lung fibrosis by inducing lipogenic differentiation in myofibroblasts through BMP2-PPARγ signaling and AMPK-dependent collagen reduction.

Targeting the DNM3OS / miR-199a~214 cluster for the treatment of fibroproliferative diseases

This study identifies DNM3OS as a key regulator of fibroblast activation via miRNAs, offering a therapeutic target for fibrotic diseases like IPF.