H. Ghalei

Differential roles of putative arginine fingers of AAA+ ATPases Rvb1 and Rvb2

This study identifies distinct roles of arginine fingers in Rvb1 and Rvb2 ATPases, showing how changes in their active sites affect catalytic activity, protein interactions, and cellular functions.

Sinefungin, a natural nucleoside analog of S-adenosyl methionine, impairs the pathogenicity of Candida albicans

This study shows that sinefungin, a nucleoside analog, reduces the pathogenicity of C. albicans by impairing hyphal growth, biofilm formation, and adhesion to human cells without harming human cells.

The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops

The paper identifies DDX1 as an interactor of the RNA exosome subunit EXOSC3 and shows that their interaction is reduced during DNA damage, affecting R-loop levels in neuronal cells.

in vivo RNA structural probing of guanine and uracil nucleotides in yeast

This study develops methods to probe guanine and uracil RNA structures in yeast using chemical modifications, showing PGO is effective for guanine and CMCT for uracil without affecting cell viability.

Ribosomal RNA 2'-O-methylations regulate translation by impacting ribosome dynamics

This study shows that 2'-O-methylations on rRNA regulate translation by affecting ribosome dynamics and eIF1 binding in yeast.

An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7

The paper determines the structure of an 80S-like ribosome assembly intermediate, revealing how Tsr1 and Dim1 coordinate to regulate Fap7 and enable quality control during ribosome maturation.