Author

A. Hagelkrueys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

G. Jonsson· 2 shared J. M. Penninger· 2 shared A. Bestehorn· 1 shared A. Kautzky-Willer· 1 shared A. Kavirayani· 1 shared A. Leopoldi· 1 shared A. Marco· 1 shared A. Meixner· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

G. Jonsson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis

C. Zhu, V. Stolz, N. Simonovic, O. Al-Rubaye, T. Vcelkova, V. Moos, L. Hess, A. Hagelkrueys, M. Madern, W. Reiter, A. Meixner, C. Bock, M. Hartl, W. Ellmeier, C. Seiser

This study shows that inhibiting HDAC1 catalytic activity in T cells prevents experimental autoimmune encephalomyelitis by reducing proinflammatory cytokines and effector functions.

bioRxiv · Apr 14, 2023 · PreprintImmunology

Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis

D. Cikes, M. Leutner, S. J. - F. Cronin, M. Novatchkova, L. Pfleger, R. Klepochova, E. Rullman, T. Gustafsson, A. Hagelkrueys, C. Knauf, C. Moro, M. Krebs, A. Kautzky-Willer, M. Krssak, M. Orthofer, , N. Viguerie

This study identifies Gpcpd1-GPC metabolic pathway perturbation in aging muscle as a driver of glucose intolerance.

bioRxiv · Oct 26, 2021 · PreprintPhysiology

A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

E. Garreta, P. Prado, M. L. Stanifer, V. Monteil, C. Hurtado del Pozo, A. Ullate-Agote, A. Vilas-Zornoza, J. P. Romero, G. Jonsson, R. Oria, A. Leopoldi, A. Hagelkrueys, D. Moya-Rull, F. Gonzalez, A. Marco, , N. Montserrat

This study shows that a diabetic environment increases SARS-CoV-2 susceptibility in kidney organoids and patients by upregulating ACE2, which is critical for viral replication.

bioRxiv · Aug 13, 2021 · PreprintCell Biology

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

C. Gomez Diaz, G. Jonsson, K. Schodl, L. Deszcz, A. Bestehorn, K. Eislmayr, J. Almagro, A. Kavirayani, L. M. Fennell, A. Hagelkrueys, P. Kovarik, J. M. Penninger, F. Ikeda

This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.

bioRxiv · Apr 13, 2021Cell Biology