W. Ellmeier

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

This study shows NCOR1 regulates Treg cell differentiation and suppressive function by maintaining transcriptional integrity in both naive and effector states.

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

Single-cell profiling uncovers regulatory programs of pathogenic Th2 cells in allergic asthma

This study uses scRNA-seq to identify two distinct subsets of pathogenic Th2 cells in allergic asthma and establishes an in vitro model to study their regulation.

Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis

This study shows that inhibiting HDAC1 catalytic activity in T cells prevents experimental autoimmune encephalomyelitis by reducing proinflammatory cytokines and effector functions.

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

This study identifies Rin-like as a negative regulator of Tfh differentiation in mice and humans, showing its role in CD28 signaling and endocytosis.

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis

This study shows that DNMT1 is essential for maintaining tumor-specific methylation during NPM-ALK driven T cell lymphomagenesis, despite oncogenic signaling.