Intracellular Aβ42 aggregation leads to cellular thermogenesis
C. W. Chung, A. D. Stephens, T. Konno, E. Ward, E. Avezov, C. F. Kaminski, A. Hassanali, G. S. Kaminski Schierle
This paper shows that Aβ42 aggregation in live cells increases intracellular temperature, which can be mitigated by aggregation inhibitors and is independent of mitochondrial damage.
bioRxiv · Mar 30, 2022Biophysics