Author

A. Haynes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

L. Giacani· 4 shared E. Romeis· 3 shared A. L. Greninger· 2 shared M. Eguiluz· 2 shared N. A. P. Lieberman· 2 shared O. Mitja· 2 shared S. A. Lukehart· 2 shared A. Addetia· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMicrobiology

L. Giacani

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Novel Pan-Proteome Array for High-Throughput Profiling of the Humoral Response to Treponema pallidum subsp. pallidum: a Pre-Clinical Study

J. J. Campo, E. Romeis, A. Oberai, J. Pablo, C. Hung, A. Teng, A. D. Shandling, A. Phan, A. Haynes, L. Giacani

This study develops a pan-proteome array to profile the humoral response to Treponema pallidum in rabbits, identifying antigens for early diagnosis and vaccine development.

bioRxiv · Apr 20, 2024 · PreprintMicrobiology

TIAM1 signaling drives prostatic budding and branching phenotypes and is a potential therapeutic target for BPH

H. Khedmatgozar, S. Dutta, M. Dominguez, D. Latour, M. Johnson, M. Fokar, I. Warraich, W. DeRiese, A. Haynes, R. J. Matusik, L. Brandi, S. Nandana, M. Tripathi

This study identifies TIAM1-RAC1 signaling as a driver of prostatic budding and branching in BPH and suggests it as a therapeutic target.

bioRxiv · Feb 2, 2024 · PreprintCell Biology

High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny

N. A. P. Lieberman, T. D. Armstrong, B. Chung, D. Pfalmer, C. M. Hennelly, A. Haynes, E. Romeis, Q.-Q. Wang, R.-L. Zhang, C.-X. Kou, G. Ciccarese, I. Dal Conte, M. Cusini, F. Drago, S.-i. Nakayama, , A. L. Greninger

The paper uses nanopore sequencing to analyze repeat regions in T. pallidum genes, revealing clade-specific patterns that align with whole genome phylogeny.

bioRxiv · Aug 2, 2022Microbiology

Longitudinal accumulation of in vivo and in vitro-grown Treponema pallidum subsp. pallidum TprK variants in the presence and absence of immune pressure

M. J. Lin, A. Haynes, A. Addetia, N. A. P. Lieberman, Q. Phung, H. Xie, T. V. Nguyen, B. J. Molini, S. A. Lukehart, L. Giacani, A. L. Greninger

This study shows that T. pallidum generates TprK sequence diversity both under immune pressure and in vitro without immune selection, highlighting the role of gene conversion in antigenic variation.

bioRxiv · Jun 26, 2021Microbiology

Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum

A. Haynes, M. Fernandez, E. Romeis, O. Mitja, K. Konda, S. Vargas, M. Eguiluz, C. Caceres, J. Klausner, L. Giacani

This paper investigates the transcriptional regulation of the TprL gene in Treponema pallidum, showing that phase variation through homopolymeric G sequences affects its expression and immune response.

bioRxiv · Sep 28, 2020Microbiology