Author

M. J. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. L. Greninger· 4 shared A. Addetia· 3 shared H. Xie· 3 shared L. Giacani· 2 shared Q. Phung· 2 shared A. Haynes· 1 shared B. J. Molini· 1 shared C. Marra· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

A. L. Greninger

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4 papers

Recent·Most cited

A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivo

K. Chiem, D. M. Vasquez, J. Silvas, J.-G. Park, M. Piepenbrink, J. Sourimant, M. J. Lin, A. L. Greninger, R. K. Plemper, J. B. Torrelles, M. R. Walter, J. C. de la Torre, J. Kobie, L. Martinez-Sobrido

This paper develops a bifluorescent-based assay to identify neutralizing antibodies against SARS-CoV-2 variants in vitro and in vivo, showing it accurately reflects viral neutralization.

bioRxiv · Jun 28, 2021Microbiology

Longitudinal accumulation of in vivo and in vitro-grown Treponema pallidum subsp. pallidum TprK variants in the presence and absence of immune pressure

M. J. Lin, A. Haynes, A. Addetia, N. A. P. Lieberman, Q. Phung, H. Xie, T. V. Nguyen, B. J. Molini, S. A. Lukehart, L. Giacani, A. L. Greninger

This study shows that T. pallidum generates TprK sequence diversity both under immune pressure and in vitro without immune selection, highlighting the role of gene conversion in antigenic variation.

bioRxiv · Jun 26, 2021Microbiology

Estimation of Full-Length TprK Diversity in Treponema pallidum subspecies pallidum

A. Addetia, M. J. Lin, Q. Phung, H. Xie, M. Huang, G. Ciccarese, I. Dal Conte, M. Cusini, F. Drago, L. Giacani, A. L. Greninger

This study uses deep sequencing to characterize full-length TprK diversity in T. pallidum strains from human infections, revealing near-complete sequence divergence and estimating high antigenic variation potential.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

Comparative Genomics and Full-Length TprK Profiling of Treponema pallidum subsp. pallidum Reinfection

A. Addetia, L. C. Tantalo, M. J. Lin, H. Xie, M.-L. Huang, C. Marra, A. L. Greninger

The paper compares genomic sequences and full-length TprK profiles of two T. pallidum isolates from the same patient to understand reinfection genetics and immune evasion mechanisms.

PLOS Neglected Tropical Diseases · Apr 6, 2020Peer-reviewedMicrobiology