Author

A. Herland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Assay:organoid / primary culture· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2

Frequent Co-Authors

T. E. Winkler· 5 shared I. Matthiesen· 4 shared E. A. Fitzgerald· 2 shared F. Rasti Boroojeni· 2 shared H. Sanchez· 2 shared J. Nawroth· 2 shared J. Sliz· 2 shared K.-J. Jang· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersBioengineering

T. E. Winkler

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Astrocyte 3D Culture and Bioprinting using Peptide Functionalized Hyaluronan Hydrogels

I. Matthiesen, M. Jury, F. Rasti Boroojeni, S. L. Ludwig, M. Holzreuter, S. Buchmann, A. A. Träger, R. Selegard, T. E. Winkler, D. E. Aili, A. Herland

This study develops a peptide-functionalized hyaluronan hydrogel for 3D astrocyte culture and bioprinting, showing no effect on cell viability and enhanced interactions with the hydrogel.

bioRxiv · Oct 13, 2022Bioengineering

Bioorthogonally Cross-Linked Hyaluronan-Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication

M. Jury, I. Matthiesen, F. Rasti Boroojeni, S. Ludwig, L. Civitelli, T. E. Winkler, R. Selegard, A. Herland, D. Aili

This paper introduces a hydrogel system for 3D neuronal cell culture using bioorthogonal chemistry to functionalize hyaluronan and poly(ethylene glycol) with laminin 521, showing improved cell viability and differentiation.

bioRxiv · Sep 27, 2021Bioengineering

Sorption of neuropsychopharmaca in microfluidic materials for in-vitro studies

T. E. Winkler, A. Herland

This study evaluates small-molecule sorption in microfluidic materials under relevant conditions, finding that tubing sorption dominates over device sorption in barrier-on-chip systems.

bioRxiv · May 26, 2021Bioengineering

Continuous monitoring reveals protective effects of N-acetylcysteine amide on an isogenic microphysiological model of the neurovascular unit

I. Matthiesen, D. Voulgaris, P. Nikolakopoulou, T. E. Winkler, A. Herland

The paper presents a BBB-on-chip model using isogenic hiPSC-derived cells to study nitrosative stress and the protective effects of N-acetylcysteine amide, with high temporal resolution.

bioRxiv · Mar 26, 2021Bioengineering

Low-cost microphysiological systems: Feasibility study of a tape-based barrier-on-chip system for small intestine modeling

T. E. Winkler, M. Feil, E. F. Stronkman, I. Matthiesen, A. Herland

This paper presents a low-cost microphysiological system using tape-based barriers for small intestine modeling, showing comparable permeability and improved epithelial polarization compared to Transwell cultures.

bioRxiv · Jan 6, 2020Bioengineering

Liver-Chip: Reproducing Human and Cross-Species Toxicities

K.-J. Jang, M. Otieno, J. Ronxhi, H.-K. Lim, L. Ewart, K. Kodella, D. Petropolis, G. Kulkarni, J. Rubins, D. Conegliano, J. Nawroth, D. Simic, W. Lam, M. Singer, E. Barale, , G. Hamilton

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

bioRxiv · May 15, 2019 · PreprintPharmacology & Toxicology

A robotic platform for fluidically-linked human body-on-chips experimentation

R. Novak, M. Ingram, S. Clauson, D. Das, A. Delahanty, A. Herland, B. Maoz, S. S. F. Jeanty, M. R. Somayaji, M. Burt, E. Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D. B. Chou, , B. Swenor

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.

bioRxiv · Mar 6, 2019 · PreprintBioengineering

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties

T.-E. Park, N. Mustafaoglu, A. Herland, R. M. Hasselkus, R. Mannix, E. A. FitzGerald, R. Prantil-Baun, A. Watters, O. Henry, M. Benz, H. Sanchez, H. J. McCrea, L. Christova Goumnerova, H. W. Song, S. P. Palecek, , D. E. Ingber

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.

bioRxiv · Nov 29, 2018 · PreprintBioengineering