G. Hamilton

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei

This study uses Nanopore sequencing to show that DNA replication compartmentalization in Trypanosoma brucei affects genome stability and instability by influencing VSG gene recombination and chromosome stability.

Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip

This study develops a human Proximal Tubule Kidney-Chip to assess renal transporter-based drug-drug interactions and demonstrates its ability to predict clinical outcomes and clearance values.

Cell-type specific transcriptional networks in root xylem adjacent cell layers

The paper identifies cell-type specific transcriptional networks in Arabidopsis root xylem-adjacent layers using promoter tagging and chromatin analysis, revealing ZAT6's role in regulating Na+ accumulation.

Effective Computational Framework for Pre-Interventional Planning of Peripheral Arteriovenous Malformations with In Vivo and In Vitro Validation

This paper develops a computational framework to simulate AVM haemodynamics and predict embolisation outcomes, validated with clinical and experimental data.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

Liver-Chip: Reproducing Human and Cross-Species Toxicities

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

Trypanosoma brucei ribonuclease H2A is an essential enzyme that resolves R-loops associated with transcription initiation and antigenic variation

This study shows that TbRH2A is essential for resolving R-loops and preventing DNA damage in T. brucei, with distinct roles in RNA Pol II and Pol I transcription.