Author

A. J. Davidson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:organoid / primary culture· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Przepiorski· 2 shared J. A. Hollywood· 2 shared N. A. Hukriede· 2 shared S. C. Watkins· 2 shared A. C. Stowie· 1 shared A. Chatterjee· 1 shared A. Hill· 1 shared A. Silva-Barbosa· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

A. Przepiorski

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization, and de novo cell types

J. C. Maggiore, R. LeGraw, A. Przepiorski, J. Velazquez, C. Chaney, E. Streeter, A. Silva-Barbosa, J. Franks, J. Hislop, A. Hill, H. Wu, K. Pfister, S. E. Howden, S. C. Watkins, M. Little, , N. A. Hukriede

This paper genetically engineers an endothelial niche in human kidney organoids to enhance vascularization, maturation, and the emergence of new cell types.

bioRxiv · May 30, 2023Bioengineering

Cell-type specific circadian bioluminescence rhythms in Dbp reporter mice

C. B. Smith, V. van der Vinne, E. McCartney, A. C. Stowie, T. L. Leise, B. Martin-Burgos, P. C. Molyneux, L. A. Garbutt, M. H. Brodsky, A. J. Davidson, M. E. Harrington, R. Dallmann, D. R. Weaver

This study develops Dbp reporter mice to monitor cell-type specific circadian rhythms in vivo and ex vivo, revealing differences in rhythmicity recovery between locomotor activity and hepatic bioluminescence.

Journal of Biological Rhythms · Jan 13, 2022Peer-reviewedPhysiology

Cystinosin deficient rats recapitulate the phenotype of nephropathic cystinosis

J. A. Hollywood, P. K. Kallingappa, P. Y. Cheung, R. M. Martis, S. Sreebhavan, A. Chatterjee, E. J. Buckels, B. G. Matthews, P. M. Lewis, A. J. Davidson

This paper develops a new cystinosis rat model using CRISPR/Cas9 to recapitulate the disease phenotype and progression more accurately than existing models.

bioRxiv · Jun 29, 2021Physiology

WASP restricts active Rac to maintain cells’ front-rear polarisation

C. Amato, P. A. Thomason, A. J. Davidson, K. Swaminathan, S. Ismail, L. M. Machesky, R. H. Insall

This study shows WASP restricts active Rac to the front of cells to maintain front-rear polarity, but its interaction with Rac is not required for actin polymerization.

bioRxiv · Apr 10, 2019Cell Biology

Use of human iPSCs and kidney organoids to develop a cysteamine/mTOR inhibition combination therapy to treat cystinosis

J. A. Hollywood, A. Przepiorski, P. T. Harrison, E. J. Wolvetang, A. J. Davidson, T. M. Holm

This study uses human iPSCs and kidney organoids to show that combining cysteamine and mTOR inhibition improves cystinosis treatment by correcting multiple disease phenotypes.

bioRxiv · Apr 1, 2019Pathology

Enhancing acute kidney injury regeneration by promoting cellular dedifferentiation in zebrafish

L. Brilli Skvarca, H. I. Han, E. B. Espiritu, M. A. Missinato, E. R. Rochon, M. D. McDaniels, B. L. Roman, J. S. Waxman, S. C. Watkins, A. J. Davidson, M. Tsang, N. A. Hukriede

This study shows PTBA enhances AKI recovery in zebrafish by promoting RTEC dedifferentiation and reducing fibrosis, with effects also observed in cardiac injury.

bioRxiv · Oct 4, 2018Pharmacology & Toxicology