Author

A. J. Deshpande

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Deshpande· 3 shared E. Ruppin· 2 shared K. Barbosa· 2 shared Y. Sun· 2 shared A. Brown· 1 shared A. Ghosh· 1 shared A. Khateb· 1 shared A. Minkina· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

A. Deshpande

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3 papers

Recent·Most cited

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

K. Barbosa, A. Deshpande, M. E. Perales, P. Xiang, R. Murad, A. Minkina, N. A. Robertson, F. Schischlik, X. Lei, Y. Sun, A. Brown, D. Amend, I. Jeremias, J. G. Doench, K. Humphries, , A. J. Deshpande

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

bioRxiv · Dec 12, 2022 · PreprintCancer Biology

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

A. Khateb, A. Deshpande, Y. Feng, J. S. Lee, I. Lazar, B. Fabre, Y. Li, D. Finlay, Y. Fujita, T. Zhang, J. Yin, I. Pass, I. Livneh, C. Burian, J. R. Mason, , Z. A. Ronai

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

bioRxiv · Oct 25, 2020Cancer Biology

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1

K. Barbosa, A. Ghosh, A. Deshpande, B.-R. Chen, Y. Sun, M. Weetall, S. A. Armstrong, S. K. Bohlander, A. J. Deshpande

This study shows that BMI1 is overexpressed in CALM-AF10-positive leukemias and that inhibiting BMI1 with PTC209 or PTC596 reduces leukemia growth and prolongs survival.

bioRxiv · Jan 18, 2019Cancer Biology