Author

D. C. Hay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. J. Drake· 2 shared M. C. Sinton· 2 shared A. Li· 1 shared A. Prasnicka· 1 shared A. Thakker· 1 shared A. Unciti-Broceta· 1 shared B. Chen· 1 shared B. Lucendo Villarin· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

A. J. Drake

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Author profile →

5 papers

Recent·Most cited

Clearance of protein aggregates during cell division

S. Du, Y. Wang, B. Chen, S. Xie, K. Y. Chan, D. C. Hay, T. G. Chew

The paper investigates how protein aggregates are cleared during cell division, finding that ER reorganization and BiP-mediated clearance occur during mitosis and cytokinesis.

bioRxiv · Feb 10, 2024Cell Biology

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

E. H. Gilglioni, A. Li, W. Saint-Pierre Wijckmans, T.-K. Shen, I. Perez-Chavez, G. Hovhannisyan, M. Lisjak, J. Negueruela, V. Vandenbempt, J. Bauza-Martinez, J. M. Herranz, D. Ezerina, S. Demine, Z. Feng, T. Vignane, , E. N. Gurzov

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

bioRxiv · Dec 1, 2023 · PreprintCancer Biology

Single-cell morphological tracking of liver cell states to identify small-molecule modulators of liver differentiation

R. E. Graham, R. Zheng, J. Wagner, A. Unciti-Broceta, D. C. Hay, S. J. Forbes, V. L. Gadd, N. O. Carragher

bioRxiv · Nov 15, 2023Cell Biology

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles, S. Wernig-Zorc, J. P. Thomson, P. D. Walker, A. Thakker, G. G. Lavery, C. Ludwig, D. A. Tennant, D. C. Hay, A. J. Drake

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

bioRxiv · Jun 23, 2020Biochemistry

Nonalcoholic fatty liver disease is associated with decreased hepatocyte mitochondrial respiration but not mitochondrial number

M. C. Sinton, J. Meseguer-Ripolles, B. Lucendo-Villarin, M. J. Lyall, R. N. Carter, N. M. Morton, D. C. Hay, A. J. Drake

This study shows that NAFLD is linked to reduced mitochondrial respiration but not mitochondrial number or fragmentation in a human stem cell model.

bioRxiv · Mar 10, 2020 · PreprintBiochemistry