M. M. Gottesman

A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells

The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species

This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.

Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and their Zebrafish Homologs at the Blood-Brain Barrier

The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier

The paper identifies Abcg2a as the functional homolog of human ABCG2 at the zebrafish blood-brain barrier, showing its substrate overlap and BBB localization.

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

This study shows that P-glycoprotein (P-gp) and ABCG2 confer resistance to ferroptosis inducers, and some inducers inhibit these transporters, suggesting potential drug-drug interactions.

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

This study identifies two novel heterodimers of ABCB5{beta} in melanoma using bioluminescence resonance energy transfer, co-immunoprecipitation, and proximity ligation assay.

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

Spatial control of oxygen delivery to 3D cultures alters cancer cell growth and gene expression

The paper compares cancer cell growth and gene expression in different oxygen environments, finding that controlled oxygen delivery in 3D cultures better mimics physiological conditions.