Author

J. J. Vanportfliet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

P. Li· 2 shared A. K. Coleman· 1 shared A. Mohan· 1 shared A. P. West· 1 shared B. Wang· 1 shared B. Zhao· 1 shared C. G. Weindel· 1 shared C. Mabry· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

P. Li

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Y. Lei, J. J. Vanportfliet, Y.-F. Chen, J. D. Bryant, Y. Li, D. Fails, S. Torres Odio, K. B. Ragan, J. Deng, A. Mohan, B. Wang, O. Brahms, S. Yates, M. Spencer, C. W. Tong, , A. P. West

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

bioRxiv · May 30, 2022Immunology

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

C. G. Weindel, X. Zhao, E. Martinez, S. L. Bell, K. J. Vail, A. K. Coleman, J. J. VanPortfliet, B. Zhao, C. Mabry, P. Li, P. West, J. Karpac, K. L. Patrick, R. O. Watson

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

bioRxiv · Nov 18, 2021 · PreprintImmunology